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Found 61 clinical trials
PHASE 1/2 STUDY TO EVALUATE PALBOCICLIB (IBRANCE®) IN COMBINATION WITH IRINOTECAN AND TEMOZOLOMIDE OR IN COMBINATION WITH TOPOTECAN AND CYCLOPHOSPHAMIDE IN PEDIATRIC PATIENTS WITH RECURRENT OR REFRACTORY SOLID TUMORS

A study to learn about safety and find out maximum tolerable dose of palbociclib given in combination with chemotherapy (temozolomide with irinotecan or topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent or refractory solid tumors (phase 1). Phase 2 to learn about the efficacy of palbociclib in …

biological therapy
measurable disease
biological factors
bone marrow procedure
irinotecan
  • 129 views
  • 19 Oct, 2022
  • 81 locations
Methionine PET/CT Studies In Patients With Cancer

The purpose of this study is to test the usefulness of imaging with radiolabeled methionine in the evaluation of children and young adults with tumor(s). Methionine is a naturally occurring essential amino acid. It is crucial for the formation of proteins. When labeled with carbon-11 (C-11), a radioactive isotope of …

nervous
MRI
residual tumor
cancer
positron emission tomography
  • 53 views
  • 04 Oct, 2022
  • 1 location
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

pleural effusions
central nervous system tumor
cancer
cytotoxic chemotherapy
alpha-fetoprotein
  • 1032 views
  • 25 Oct, 2022
  • 108 locations
INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt)

The aim of this trial is to determine preliminary activity of the combination treatment with nivolumab and entinostat in children and adolescents with high risk refractory/relapsed/progressive tumors harboring a high mutational load, high PD-L1 mRNA expression or focal MYC(N) amplification and explore activity in biomarker low tumors (low mutational load, …

dipg
ependymoma
cancer
diffuse intrinsic pontine glioma
sarcoma
  • 0 views
  • 04 Oct, 2022
  • 14 locations
PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma (PRiME)

The primary goal of this prospective clinical trial is to evaluate the safety of PEP-CMV in patients with recurrent medulloblastoma and malignant glioma. Patients with histologically-proven

initial diagnosis
temozolomide
MRI
brain mri
montanide isa-51
  • 22 views
  • 19 Jun, 2022
  • 1 location
DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma.

renal function
medulloblastoma
  • 0 views
  • 04 Oct, 2022
  • 9 locations
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

survival (EFS) and overall survival (OS). The study population will be high-risk patients (non-Wnt and non-Shh sub-groups) with medulloblastoma, and for all patients with central nervous system (CNS

blood transfusion
vincristine
MRI
platelet count
glomerular filtration rate
  • 197 views
  • 23 Mar, 2022
  • 61 locations
Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults With Recurrent Medulloblastoma

medulloblastoma and to assess the antitumor activity of simultaneous infusions of panobinostat (MTX110) into the fourth ventricle of the brain or resection cavity in patients with recurrent medulloblastoma based

posterior fossa tumors
blood transfusion
MRI
tumor resection
platelet count
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Pilot Trial of Real Time Drug Screening and Genomic Testing to Determine an Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma (PNOC027)

child and young adult with medulloblastoma to receive the most effective and least toxic therapies currently available, and will pave the way for improved understanding and treatment of these tumors in

initial diagnosis
nitrosoureas
cancer
platelet count
anticonvulsants
  • 0 views
  • 23 Oct, 2022
  • 3 locations
  • 0 views
  • 27 Oct, 2022
  • 1 location