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Found 39 clinical trials
GFR 4 CAR T Cells in MTC Patients

-stimulatory domains (referred to as "CART-GFRa4 cells") in patients with incurable medullary thyroid cancer (MTC).

  • 0 views
  • 04 Sep, 2021
  • 1 location
Imatinib + MTC in Relapsed / Refractory Acute Myeloid Leukemia (AML)

The purpose of this study is to show superiority in complete responses of combination therapy MTC plus Glivec in patients with refractory or relapsed AML compared to a historical control

serum bilirubin level
mitoxantrone
secondary acute myeloid leukemia
refractory acute myeloid leukemia (aml)
  • 15 views
  • 07 Nov, 2020
  • 1 location
Niraparib in Combination With Cabozantinib (XL184) in Patients With Advanced Urothelial Cancer (NICARAGUA)

(VEGFR1-3), RET, AXL, FLT3 and KIT. Cabozantinib has been approved by the FDA for clinical treatment of progressive, metastatic medullary thyroid cancer. Recently published trials have demonstrated

transitional cell carcinoma
RET
kinase inhibitor
growth factor
metastatic cancer
  • 46 views
  • 22 Sep, 2021
  • 12 locations
A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

medullary thyroid cancer (MTC) that cannot be removed by surgery or has spread to other parts of the body. Participants who are assigned to the standard treatment and discontinue due to progressive disease

measurable disease
RET
metastasis
cancer
progressive disease
  • 18 views
  • 22 Sep, 2021
  • 226 locations
A Study of LOXO-292 in Participants With Advanced Solid Tumors RET Fusion-Positive Solid Tumors and Medullary Thyroid Cancer

) administered orally to participants with advanced solid tumors, including rearranged during transfection (RET)-fusion-positive solid tumors, medullary thyroid cancer (MTC) and other tumors with RET activation

measurable disease
RET
cfdna
cancer
kidney function test
  • 1244 views
  • 23 Sep, 2021
  • 161 locations
Phase 1/2 Study of the Highly-selective RET Inhibitor Pralsetinib (BLU-667) in Patients With Thyroid Cancer Non-Small Cell Lung Cancer and Other Advanced Solid Tumors

of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors.

RET
metastatic nsclc
metastatic cancer
cancer
nucleic acid
  • 1632 views
  • 09 Sep, 2021
  • 93 locations
A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors

This is an open-label, multi-center Phase 1/2 study of oral LOXO-292 in pediatric participants with an activating rearranged during transfection (RET) alteration and an advanced solid or primary CNS tumor.

measurable disease
RET
kidney function tests
cns tumor
metastasis
  • 29 views
  • 22 Sep, 2021
  • 33 locations
A Phase II Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma

): Renal medullary carcinoma (RMC) Cohort 5 (Closed for enrollment): Epithelioid sarcoma (ES) Cohort 6 (Opened for enrollment): Epithelioid sarcoma (ES) undergoing mandatory tumor biopsy

monoclonal antibodies
beta human chorionic gonadotropin
growth factor
cancer
solid tumour
  • 2 views
  • 19 Aug, 2021
  • 25 locations
18F-DOPA II - PET Imaging Optimization

A single centre non-randomized, non-blinded phase III prospective cohort study of 18F-DOPA PET/CT imaging in specific patient populations: Pediatric patients (less than 18 years old) with congenital hyperinsulinism. Pediatric patients (less than 18 years old) with neuroblastoma. Pediatric (less than 18 years old) or Adult patients (18 or older) with …

  • 0 views
  • 29 Apr, 2021
  • 1 location
  • 0 views
  • 02 Aug, 2021
  • 13 locations