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Found 70 clinical trials
A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder (VA-BRAVE)

VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous (in the belly area) formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence compared to the daily sublingual (under the tongue) buprenorphine formulation at a target dose of …

  • 17 Jun, 2022
  • 18 locations
EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke (DISTAL)

Acute ischemic stroke (AIS) is one of the main causes of disability and loss of quality adjusted life years. This study is to analyze whether endovascular therapy (EVT) in addition to best medical treatment (BMT) reduces the degree of disability and dependency in daily activities after a Medium Vessel Occlusion …

  • 30 Jun, 2022
  • 5 locations
Mindful Body Awareness With Medication Treatment for Opioid Use Disorder

The national opioid epidemic requires development of real-world evidence-based treatments for opioid use disorder, including adjuncts to Medication Treatment (MT). Interventions are needed that

  • 17 Nov, 2021
  • 5 locations
NET Device for Treating Opioid Use Disorder

) without use of Medication treatment for OUD (MOUD) for persons who have expressed a desire to be opioid abstinent without use of MOUD.

  • 02 Jan, 2022
  • 1 location
Long-acting Buprenorphine vs. Naltrexone Opioid Treatments in CJS-involved Adults

is non-inferior to XR-NTX when comparing retention-in-study-medication treatment options.

  • 24 Mar, 2022
  • 2 locations
Coordinating Opioid Use Treatment Through Medical Management With Infection Treatment (Project COMMIT)

This study seeks to test a new model of care (ID/LAB) in which opioid use disorder (OUD) is managed by infectious disease (ID) specialists and hospitalists concurrent with management of the OUD-related infections, using long-acting injectable buprenorphine (LAB), followed by referral as soon as possible after hospital discharge to community …

  • 26 Nov, 2021
  • 3 locations
Comparison of Two Different Drug Regimens for Medical Treatment of Early Pregnancy Loss

The purpose of this study is to compare the safety and efficacy of a combination of two drugs (mifepristone and misoprostol) to only one of these drugs (misoprostol) in medical management of missed miscarriage up to 13+6 weeks of pregnancy (early pregnancy loss). The investigators aim to enroll 220 patients …

  • 27 Nov, 2021
  • 1 location
Surmounting Withdrawal to Initiate Fast Treatment With Naltrexone

This study compares two methods of initiating treatment with extended-release naltrexone (XR-NTX) when implemented at community-based inpatient or residential programs. The primary goal of this hybrid effectiveness-implementation study is to determine whether the Rapid Method (5-7 day long) is non-inferior to a Standard Method (13-day long) on the primary effectiveness …

  • 26 Sep, 2021
  • 6 locations
Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT (SMART-PDA)

Background: Among preterm infants, those born at a gestational age less than 26 weeks are considered the most vulnerable with a high risk of short- and long-term health problems that include chronic lung disease, brain bleeds, gut injury, kidney failure and death. Patent ductus arteriosus (PDA) is the most common …

  • 22 Mar, 2022
  • 1 location
Conus Medullaris Stimulation With 5 Columns Lead Versus Medical Treatment in Refractory Pudendal Neuralgia

Pudendal neuralgia is a frequent diagnosis in pain clinics. This perineal pain has devastating effects on patient's quality of life. Today, 30% of patients are refractory to pain management and surgical procedure. The neuropathic characteristics of the pain in these patients lead us to test the efficiency of spinal cord …

  • 23 Jan, 2021
  • 8 locations