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Found 302 clinical trials
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A phase III randomized, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF).

A phase III randomized, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF).

  • 378 views
  • 25 Mar, 2021
  • 1 location
featured
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

This study will evaluate the safety and effectiveness of treating patients with severe aplastic anemia (SAA) or myelopdysplastic syndrome (MDS) with both peripheral blood stem cells from a family member and umbilical cord blood stem cells from an unrelated donor. Patients with SAA or MDS for whom other treatments have …

anemia studies
myelodysplastic syndromes
myelodysplastic syndrome (mds)
anemia
aplastic anemia
  • 48 views
  • 22 Dec, 2020
  • 1 location
LTOT in COPD Patients With Moderate Chronic Hypoxemia and Chronic Heart Failure

medical therapy for both conditions can correct the moderate hypoxemia by improving the underlying mechanisms without the need of LTOT. If this hypothesis is correct, the study will provide a

medical therapy
COPD
pulmonary disease
  • 31 views
  • 07 Nov, 2020
  • 1 location
BioVentrix Revivent TC System Clinical Study

A prospective, multi-center, dual-arm pivotal study of the BioVentrix Revivent TC System, with 2:1 study vs. active concurrent control group allocation ratio. This study will include 126 patients of which 84 patients will be treated with the investigational device and 42 patients will be included in an active control group.

6-minute walk test
heart failure
medical therapy
ejection fraction
  • 44 views
  • 20 Mar, 2021
  • 37 locations
Efficacy of Medical Therapy in Women and Men With Angina and Myocardial Bridging

The proposed clinical trial is relevant to public health because it is expected to expand the differential diagnosis and provide an evidence--based therapy for the large population of patients with angina in the absence of obstructive CAD who currently remain undiagnosed and untreated. It, therefore, upholds an important part of …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Revascularization Versus Optimal Medical Therapy of Chronic Total Coronary Occlusions on Left Ventricular Ischemia Reduction

Rationale: Randomized trials could not yet establish favourable outcomes of CTO PCI on hard endpoints such as ejection fraction or mortality, when compared to optimal medical therapy. However

  • 0 views
  • 24 Jan, 2021
  • 1 location
Comparison of Stenting Versus Best Medical Therapy for Treatment of Ostial Renal Artery Stenosis: a Trial in Patients With Advanced Atherosclerosis

Renal artery stenosis (RAS) usually refers to a disease of the large extra-renal arterial vessels and most frequently is caused by atherosclerotic obstructions. The prevalence of atherosclerotic RAS increases with age, male gender, traditional cardiovascular risk factors (hypertension, diabetes, smoking, hyperlipidemia) and atherosclerotic comorbidities like coronary artery or peripheral artery …

arterial vessels
renal artery stenosis
diabetes
medical therapy
endovascular interventions
  • 14 views
  • 07 Nov, 2020
  • 1 location
Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies

Phase II, prospective, randomized, multicenter, open-label, pilot clinical trial comparing remote ischemic conditioning (RIC) plus standard medical therapy to standard medical therapy alone, in

  • 10 views
  • 29 Aug, 2021
  • 3 locations
Micronized Purified Flavonoid- Fraction (MPFF) in the Management of Radiation Proctitis

national and multi-center trial for medical therapy of chronic radiation proctitis inducing anorectal bleedings

  • 0 views
  • 26 Jan, 2021
  • 20 locations
Transcatheter Mitral Valve Repair for the Treatment of Mitral Valve Regurgitation In Heart Failure (The EVOLVE-MR Trial)

The study compares the effectiveness of treatment with MitraClip to medical therapy in improving the reduction of cardiovascular morbidity and functional capacity at 24 months, in patients with

  • 0 views
  • 27 Jun, 2021
  • 1 location