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Found 289 clinical trials
Featured trial
A phase III randomized, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF).

A phase III randomized, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF).

  • 25 Mar, 2021
  • 1 location
Featured trial
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

This study will evaluate the safety and effectiveness of treating patients with severe aplastic anemia (SAA) or myelopdysplastic syndrome (MDS) with both peripheral blood stem cells from a family member and umbilical cord blood stem cells from an unrelated donor. Patients with SAA or MDS for whom other treatments have …

aplastic anemia
myelodysplastic syndromes
anemia studies
myelodysplastic syndrome (mds)
  • 22 Dec, 2020
  • 1 location
ContraBand™: FIH Safety & Feasibility Study (RM-20-01)

The ContraBand™ device is intended for treatment of heart failure patients who remain symptomatic despite the use of optimally tolerated guideline directed medical therapy. ContraBand™ is a

medical therapy
systolic heart failure
  • 21 Mar, 2022
  • 4 locations
BioVentrix Revivent TC System Clinical Study

A prospective, multi-center, dual-arm pivotal study of the BioVentrix Revivent TC System, with 2:1 study vs. active concurrent control group allocation ratio. This study will include 126 patients of which 84 patients will be treated with the investigational device and 42 patients will be included in an active control group.

ejection fraction
heart failure
6-minute walk test
medical therapy
  • 20 Mar, 2021
  • 37 locations
Performance and Safety of the Cardiac Microcurrent Therapy System

Patients with idiopathic dilative cardiomyopathy who have systolic left ventricular dysfunction (NYHA III - IV) despite adequate therapy according treatment guidelines of heart failure and who have a baseline left ventricular ejection fraction of 25% and 35 will receive a C-MIC System and microcurrent therapy after device implantation with optimal …

  • 10 Nov, 2021
  • 11 locations
Revascularization Versus Optimal Medical Therapy of Chronic Total Coronary Occlusions on Left Ventricular Ischemia Reduction (REVISE-CTO)

Rationale: Randomized trials could not yet establish favourable outcomes of CTO PCI on hard endpoints such as ejection fraction or mortality, when compared to optimal medical therapy. However

  • 22 Mar, 2022
  • 1 location
Efficacy of Medical Therapy in Women and Men With Angina and Myocardial Bridging

The proposed clinical trial is relevant to public health because it is expected to expand the differential diagnosis and provide an evidence--based therapy for the large population of patients with angina in the absence of obstructive CAD who currently remain undiagnosed and untreated. It, therefore, upholds an important part of …

  • 26 Jan, 2021
  • 1 location
Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies

Phase II, prospective, randomized, multicenter, open-label, pilot clinical trial comparing remote ischemic conditioning (RIC) plus standard medical therapy to standard medical therapy alone, in

  • 29 Aug, 2021
  • 3 locations
Micronized Purified Flavonoid- Fraction (MPFF) in the Management of Radiation Proctitis (MiFlaPRO)

national and multi-center trial for medical therapy of chronic radiation proctitis inducing anorectal bleedings

  • 03 Mar, 2022
  • 10 locations
Hypoxic Conditioning in Heart Failure (hypoxheart)

Heart failure impairs quality of life and exercise capacity, despite an optimal medical therapy. Alternative methods, like hypoxic conditioning coupled to exercise training, must be explored and

medical therapy
  • 03 Mar, 2022
  • 1 location