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Found 610 clinical trials
An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study

mechanical ventilation comprising individualized positive end-expiratory pressure to maximize respiratory system compliance and minimize driving pressures, individualized use of neuromuscular blocking

  • 25 Feb, 2021
  • 9 locations
Efficacy and Safety of Trimodulin in Subjects With Severe COVID-19

The objectives of the trial are to evaluate the efficacy and safety of trimodulin as add-on therapy to standard of care (SoC) compared to placebo treatment in adult hospitalized subjects with severe COVID-19. Additionally, pharmacodynamic (PD) and pharmacokinetic (PK) properties of trimodulin will be evaluated in all subjects.

  • 03 Feb, 2021
  • 11 locations
suPAR-Guided Anakinra Treatment for Management of Severe Respiratory Failure by COVID-19

The SAVE-MORE is a pivotal, confirmatory, phase III randomized clinical trial (RCT) aiming to evaluate the efficacy and safety of early start of anakinra guided by suPAR in patients with LRTI by SARS-CoV-2 in improving the clinical state of COVID-19 over 28 days as measured by the ordinal scale of …

  • 19 Feb, 2021
  • 39 locations
Anti-thrombotics for Adults Hospitalized With COVID-19 (ACTIV-4)

This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic strategies for prevention of adverse outcomes in COVID-19 positive inpatients

  • 03 Mar, 2021
  • 41 locations
Efficacy of Favipiravir in Treatment of Mild & Moderate COVID-19 Infection in Nepal

COVID-19 has affected almost all countries in the world. Every other country is constantly working towards its treatment and development of vaccines, with little to no success so far. Recently, several regimens have been tried as antiviral medicine. Among these medicines, Favipiravir is considered a broad-spectrum antiviral with the spectrum …

  • 27 Jan, 2021
  • 2 locations
Diaphragm Dysfunction During Prolonged Mechanical Ventilation

described (diaphragm disuse induced by mechanical ventilation, sepsis, initial severity upon admission), the determinants of recovery of diaphragm dysfunction are unknown, as well it has not been elucidated

  • 25 Jan, 2021
Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation

This study compare the effectiveness of dexmedetomidine as a sedative drug during NIV and the different strategies routinely used in patients with ARF of different aetiologies. Efficacy will be assessed based on absence of intubation, short term prognosis, and occurrence of medical complications.

respiratory distress
mechanical ventilation
  • 24 Jan, 2021
  • 1 location
Effect of Three Modalities of Spontaneous Breathing Tests on Respiratory Efforts in Tracheostomized Patients

Datas are lacking concerning weaning from mechanical ventilation for tracheostomized patients. In particular, the effect of different modalities of spontaneous breathing trials on respiratory

positive end expiratory pressure
pressure support
breathing tests
  • 27 Jan, 2021
  • 1 location
Evaluation of the CleanSweep Closed Suction System on Length of Mechanical Ventilation and Ventilator-Associated Events

intensive care unit. Secondary aims of this study are to evaluate the use endotracheal tube sweeping compared to closed suctioning effect on length of mechanical ventilation, length of ICU stay, length of

  • 26 Jan, 2021
  • 1 location
Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy

The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.

  • 24 Jan, 2021
  • 1 location