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Found 454 clinical trials
Inhaled Heparin for Hospitalised COVID-19 Patients (INHALE-HEP)

mechanical ventilation, will be randomised to inhaled nebulised heparin or standard care for up to 21 days or until the patient has no respiratory symptoms. All studies will collect a minimum core dataset

  • 25 Mar, 2022
  • 2 locations
Respiratory Effect of the LISA Method With Sedation by Propofol Versus Absence of Sedation. (PROLISA)

LISA Procedure . Investigators hypothesize that sedation with Propofol is safe and non-inferior to placebo for the risk of Mechanical Ventilation in the 72 hours following the procedure.

  • 18 Feb, 2022
  • 16 locations
High Flow Nasal Cannula With Noninvasive Ventilation

, spine surgery, or open abdominal procedures) to try and decrease the need for intubation with mechanical ventilation.

  • 26 Apr, 2022
  • 1 location
Speeding the Weaning up: Aggressive Screening Criteria and Higher Minimal Ventilatory Settings. (SPEED-UP)

, who receive preventive therapy with HFNC, the use of Walsh screening criteria reduces the mechanical ventilation time compared with the use of Boles criteria. Study design

  • 04 Oct, 2022
  • 1 location
Spontaneous Breathing Trial With T-piece or Inspiratory Pressure Augmentation (SBT-TIP)

investigators hypothesized that an SBT with inspiratory pressure augmentation increases initial SBT success, reduces the length of invasive mechanical ventilation (iMV) support and does not increase

  • 24 Mar, 2022
  • 2 locations
Pneumocystis Pneumonia Diagnosis in HIV- Patients (PNEUMOQUANT)

immunodeficiency virus -, in whom the evolution is faster, with mechanical ventilation often required and higher mortality, requiring a fast and early diagnosis. Routine diagnosis relies on the detection of the

HIV Infection
opportunistic infection
mechanical ventilation
  • 09 May, 2022
  • 3 locations
Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Major Surgery:a Prospective, Multicenter, Double-blind, Randomized Controlled Trial

>Outcome: 1) Primary outcome:The incidence of delirium within 5 days after surgery;The effects on postoperative NRS pain and sleep quality scores; 2)Secondary outcome:Duration of mechanical ventilation in

orthopedic surgery
major surgery
postoperative complication
mechanical ventilation
  • 17 Sep, 2022
  • 1 location
Randomized Trial of Sedative Choice for Intubation (RSI)

Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for emergency tracheal intubation have been hypothesized to effect cardiovascular complications and patient outcomes, but the optimal sedative medication for intubation of critically ill adults remains …

  • 04 Oct, 2022
  • 1 location
Assessment of the Benefit of an Inclusive Health Organization on the Prognosis of Severe Trauma Patients (TRAUMINXCLUSIF)

Appropriate management reduces the mortality of severe trauma victims. This is based on a pre-hospital medical assessment of severity, the initiation of life-saving treatments at the pre-hospital level, and referral to a hospital with human and material resources adapted to the patient's severity. The objective of this research project is …

  • 20 Jun, 2022
  • 1 location
Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions (DEXA-REFINE)

Background: There are no proven therapies specific for pulmonary dysfunction in patients with acute hypoxemic respiratory failure (AHRF) caused by infections (including Covid-19). The full spectrum of AHRF ranges from mild respiratory tract illness to severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure, and death. The efficacy of corticosteroids …

  • 10 Apr, 2022