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Found 14 clinical trials
Effects of MDMA-like Substances in Healthy Subjects

The serotonin (5-HT) and oxytocin releaser and so-called "empathogen" 3,4-methylenedioxymethamphetamine (MDMA) acutely produces positive feelings, empathy, and trust. MDMA is used recreationally

Accepts healthy volunteers
  • 50 views
  • 05 Jan, 2022
  • 1 location
Effects of MDMA Co-administration on the Response to LSD in Healthy Subjects

similar substances for the treatment of depression. The 5-HT and oxytocin releaser 3,4-methylenedioxymethamphetamine (MDMA) reliably induces positive mood up to euphoria, comfort, empathy, and feelings of

  • 36 views
  • 18 Sep, 2021
  • 1 location
Sustaining Remission From PTSD Using Tuned Vibroacoustic Stimulation (TVS) Following MDMA-Assisted Psychotherapy

related to MDMA-assisted psychotherapy for PTSD including depression, anxiety and emotion regulation. This study will test whether regular use of the Apollo wearable improves rates of sustained

Accepts healthy volunteers
  • 0 views
  • 16 May, 2022
Drug Effects on Interpersonal Interaction

We propose to use a Paired Partner design, in which subjects engage in a 45-min semi-structured conversation with one (novel) partner under the influence of MDMA and with another partner under

Accepts healthy volunteers
  • 0 views
  • 25 Nov, 2021
  • 1 location
EA for PAAS: A pRCT

in East and South-East Asia. ATS are a group of synthetic psychostimulants including methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and related substances. Although

drug dependence
anxiety
psychiatric symptoms
heroin
psychostimulant
  • 9 views
  • 15 Jun, 2021
  • 1 location
Social Anxiety MDMA-Assisted Therapy Investigation (SAMATI)

This is a randomized, open-label delayed treatment study to assess the safety and effect of MDMA-assisted therapy in treating 20 participants diagnosed with moderate-to-severe social anxiety

Accepts healthy volunteers
  • 0 views
  • 15 May, 2022
  • 1 location
A Treatment Development Study of MDMA-Assisted Psychotherapy for PTSD

This study is designed to provide information on whether the drug MDMA, combined with Cognitive Processing Therapy (CPT), is safe and helpful for people with Post Traumatic Stress Disorder (PTSD

psychotherapy
flashbacks
mdma
depression
nightmares
  • 0 views
  • 24 Mar, 2022
  • 1 location
MDMA-Assisted Psychotherapy in Veterans With Combat-Related Refractory PTSD

This will be a single-site, open-label phase 2 study designed to test the feasibility of administering MDMA in conjunction with psychotherapy for combat-related treatment-resistant PTSD in US

psychotherapy
suicidal
mdma
  • 0 views
  • 21 Aug, 2021
  • 1 location
Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD

This open-label, randomized study will assess the comparative effectiveness of two versus three active MDMA-assisted sessions in U.S. military veterans with at least moderate chronic PTSD

mdma
psychotherapy
suicidal
chronic post-traumatic stress disorder
  • 33 views
  • 25 Nov, 2021
  • 1 location
The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD.

This study aims to investigate the effects of MDMA on prefrontal and amygdala activation, and to explore the relationship between these MDMA-induced neural changes and the acute behavioral

mdma
  • 100 views
  • 23 Mar, 2022
  • 1 location