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Found 119 clinical trials
Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

This phase I trial studies the best dose and how well copanlisib when given together with nivolumab works in treating patients with Richter's transformation or transformed indolent non-Hodgkin lymphoma. Copanlisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal …

chop regimen
cancer
monoclonal antibodies
waldenstrom's macroglobulinemia
follicular lymphoma
  • 17 views
  • 09 Apr, 2022
  • 2 locations
A Study of Nemtabrutinib (MK-1026) (ARQ 531) in Participants With Selected Hematologic Malignancies

This study aims to evaluate the safety, tolerability, pharmacodynamic, and pharmacokinetic (PK) of nemtabrutinib (formerly ARQ 531) tablets in selected participants with relapsed or refractory hematologic malignancies. No formal hypothesis testing will be performed for this study.

waldenstrom's macroglobulinemia
cancer
chronic lymphocytic leukemia
follicular lymphoma
low grade lymphoma
  • 420 views
  • 15 Mar, 2022
  • 10 locations
BR101801 in Adult Patients With Advanced Hematologic Malignancies( Phase I-II)

This is a Phase I-II, multi-center, open-label, FIH study comprising of 3 study parts (Phase Ia, Phase Ib, and Phase II). The Phase Ia (dose escalation) part of the study is designed to determine the safety, tolerability, and maximum tolerated dose (MTD)/recommended dose for expansion (RP2D) of BR101801 in subjects …

waldenstrom's macroglobulinemia
follicular lymphoma
chronic lymphocytic leukemia
cancer
mantle cell lymphoma
  • 17 views
  • 08 Dec, 2021
19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers

The purpose of this study is to test the safety of 19(T2)28z1xx CAR T cells in people with relapsed/refractory B-cell cancers. The researchers will try to find the highest dose of 19(T2)28z1xx CAR T cells that causes few or mild side effects in participants. Once they find this dose, they …

lenalidomide
cancer
monoclonal antibodies
follicular lymphoma
anti-cd20 antibody
  • 17 views
  • 11 Jul, 2022
  • 1 location
Study of TG-1801 Alone or in Combination With Ublituximab in Subjects With B-Cell Lymphoma or Chronic Lymphocytic Leukemia

A Phase 1b Multi-cohort Study of TG-1801 Alone or in Combination with Ublituximab in Subjects with B-Cell Lymphoma or Chronic Lymphocytic Leukemia

lymphoma
chronic lymphocytic leukemia
monoclonal antibodies
measurable disease
anti-cd20 monoclonal antibody
  • 0 views
  • 13 Jul, 2022
  • 5 locations
CC-486, Lenalidomide, and Obinutuzumab for the Treatment of Recurrent or Refractory CD20 Positive B-cell Lymphoma

This phase I/Ib trial investigates the side effects of CC-486 and how well it works in combination with lenalidomide and obinutuzumab in treating patients with CD20 positive B-cell lymphoma that has come back (recurrent) or has not responded to treatment (refractory). Chemotherapy drugs, such as CC-486, work in different ways …

  • 0 views
  • 26 Dec, 2021
  • 1 location
A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)

(CLL/SLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), lymphoplasmacytoid lymphoma/Waldenström macroglobulinemia (LPL/WM), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL

cancer
chronic lymphocytic leukemia
follicular lymphoma
mantle cell lymphoma
chemotherapy regimen
  • 49 views
  • 21 Jul, 2022
  • 15 locations
A Study of LOXO-305 in Chinese Participants With Blood Cancer (Including Lymphoma and Chronic Leukemia)

A study of the safety, side effects, and effectiveness of LOXO-305 in Chinese adults with lymphoma or chronic leukemia who have already had standard of care treatment. Participation could last up to four years.

lymphoma
cancer
mantle cell lymphoma
renal function
tyrosine
  • 0 views
  • 22 Jul, 2022
  • 22 locations
Haploidentical BMT With Post-Transplant Cyclophosphamide and Bendamustine

The purpose of this study is to evaluate the safety of progressively substituting day +3 and +4 post-transplant cyclophosphamide (PT-CY) with post-transplant bendamustine (PT-BEN) in myeloablative (MAC) haploidentical hematopoietic cell transplantation (HHCT) for patients with hematological malignancies. The goal of the Phase 1 component of the study is to evaluate …

cancer
follicular lymphoma
mantle cell lymphoma
chronic myeloid leukemia
chemotherapy regimen
  • 31 views
  • 03 Jun, 2022
  • 1 location
Study of BGB-10188 as Monotherapy, and in Combination With Zanubrutinib, and Tislelizumab

The purpose of this study is to determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), safety and tolerability of BGB-10188 as monotherapy in participants with relapsed/refractory (R/R) mature B-cell malignancies; in combination with zanubrutinib in participants with R/R follicular lymphoma (FL), R/R mantle cell lymphoma (MCL) or …

follicular lymphoma
chronic lymphocytic leukemia
cancer
squamous cell carcinoma
breast cancer
  • 24 views
  • 23 Jul, 2022
  • 10 locations