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Found 1099 clinical trials
Zinc Intervention in Elderly for Prevention of Pneumonia (ZIPP)

Pneumonia is a major public health problem for the elderly and is one of the leading causes of hospitalization and death for this population, particularly for elderly nursing home residents. This planning grants seeks to establish a safe and effective dose of zinc supplementation with the goal to conduct a …

Accepts healthy volunteers
  • 07 Oct, 2022
  • 1 location
A Randomized,Open-label Dose-discovery Study of PEG-rhG-CSF and rhG-CSF in the Adjuvant Therapy of Aplastic Anemia Granulocyte Deficiency

This study was a single-center,open-label,randomized,dose-exploring prospective study.Patients with granulocytotic aplastic anemia who received cytokine treatment with PEG-rhG-CSF or rhG-CSF were enrolled.Clinical demographic data,disease characteristics of aplastic anemia,clinical diagnosis and treatment,laboratory data and adverse events were collected to explore the dose and safety of PEG-rhG-CSF and rhG-CSF in patients with severe …

  • 10 Oct, 2022
  • 1 location
The Primary Objective of This Study is to Evaluate Efficacy and Safety of AVTX-803 in Patients With Leukocyte Adhesion Deficiency Type II

The primary objective of this study is to evaluate the efficacy and safety of AVTX-803 compared to withdrawal in patients with Leukocyte Adhesion Deficiency, Type II (LAD II).

  • 04 Oct, 2022
  • 1 location
A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation (CHOMP)

either mismatch repair deficiency (dMMR) or biallelic inactivation of CDK12 (CDK12-/-). The secondary objectives involve determining the frequency with which dMMR and CDK12-/- occur in this patient

  • 18 Feb, 2022
  • 8 locations
Efficacy of 1% Metformin Gel Mixed With PRF in Augmenting Narrow Ridge (MF)

This study aimed to evaluate the efficacy of 1% metformin gel mixed with PRF, in horizontal ridge augmentation with the split-crest technique, for implant placement.

Accepts healthy volunteers
  • 28 Jun, 2022
  • 1 location
Safety and Efficacy of Argatroban Applicated in Anticoagulation of V-V ECMO

Unfractionated heparin is most common in the anticoagulation management of V-V ECMO. However, many side effects of unfractionated heparin, such as HIT, antithrombin deficiency, etc seriously

  • 16 Jul, 2021
  • 1 location
Study of OsrhAAT or Placebo in Healthy Volunteers

A Phase 1, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Single Ascending Doses of OsrhAAT in Healthy Volunteers

platelet count
Accepts healthy volunteers
body mass index
absolute neutrophil count
  • 06 May, 2022
  • 1 location
Cultivated Autologous Oral Mucosal Epithelial Transplantation

Earlier protocol for cultivated oral mucosal epithelial transplantation (COMET) requires trypsin/EDTA to isolate epithelial cells from tissue, and uses murine 3T3 cells as feeder cells, which results in biosafety concern. This study uses collagenase instead of trypsin/EDTA to isolate epithelial cells, and does not use 3T3 cells co-culture, so as …

Accepts healthy volunteers
  • 06 Feb, 2022
  • 1 location
Phase IIb Pre-pivotal Study to Assess the Safety and Efficacy of the IUB SEAD™ Device in Women Suffering From Heavy Menstrual Bleeding (HMB) (HMB)

One of the AUB symptoms, heavy menstrual bleeding (HMB), can lead to iron deficiency and iron deficiency anemia and in acute and severe cases, can necessitate emergency medical care. This

iron deficiency
sound measurement
serum pregnancy test
  • 21 Oct, 2022
  • 1 location
Pamiparib in mCRPC With HRD or BRCA1/2 Mutation

The purpose of this study is to assess the efficacy of a PARP inhibitor, Pamiparib, in metastatic castration-resistant prostate cancer patients with homologous recombination deficiency or BRCA 1

  • 30 Apr, 2022
  • 1 location