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Found 1102 clinical trials
Pneumocystis Pneumonia Diagnosis in HIV- Patients (PNEUMOQUANT)

infections classifying patients infected with human immunodeficiency virus (human immunodeficiency virus +) at the stage acquired immune deficiency syndrome. Data from the french Institute for Health Watch

corticosteroids
AIDS
cytostatics
immunodeficiency
deficiency
  • 3 views
  • 09 May, 2022
  • 3 locations
Digital Support Systems to Improve Child Health and Development in Peru (DigitalECD)

About 250 million children under age five are at risk of not reaching their developmental potential due to continued exposure to ill health, malnutrition and lack of appropriate learning

  • 0 views
  • 22 Mar, 2022
  • 1 location
Mass Campaigns With Fractional Dose Pneumococcal Vaccines in Sub-Saharan Africa (fPCV) (fPCV)

The aim of this study is to assess the impact of a mass campaign with a single, fractional dose of Pneumosil®, a PCV10, on VT carriage. A 20% fractional dose (1/5th) will be used as a practical formulation to prepare and administer. This study will assess whether the impact of …

Accepts healthy volunteers
  • 0 views
  • 17 Jun, 2022
  • 1 location
Community Health Azithromycin Trial in Burkina Faso (CHAT)

An estimated 7.7 million pre-school aged children die each year, the majority from infectious diseases. Mass azithromycin distributions for trachoma may have the unintended benefit of reducing childhood mortality. We recently demonstrated the biannual mass azithromycin distribution significantly reduces all-cause child mortality in a cluster randomized trial (MORDOR I) conducted …

Accepts healthy volunteers
  • 0 views
  • 25 Oct, 2022
  • 1 location
Twice Against Thrice-weekly Hemodialysis (TATH)

Hemodialysis is the most worldwide prescribed renal replacement therapy for patients with end-stage renal disease. The frequency of sessions per week remains a debatable issue. In the majority of developed Western and Asian countries, patients on chronic hemodialysis are undergoing three dialysis sessions weekly. In developing countries and some developed …

chronic hemodialysis
hypertension
renal replacement therapy
chronic renal failure
  • 124 views
  • 26 Feb, 2022
  • 1 location
Gene Therapy for Pyruvate Kinase Deficiency (PKD)

This is an open-label Phase I trial to evaluate the safety of a hematopoietic cell-based gene therapy for patients with Pyruvate Kinase Deficiency (PKD).

  • 0 views
  • 17 Feb, 2022
  • 3 locations
Stem Cell Therapy for Limbal Stem Cell Deficiency

This phase I study will collect preliminary information on the activity and safety of cLSC. We will investigate the ability to manufacture and transplant cLSC onto the cornea successfully at the time of surgery (feasibility), and have cLSC begin to populate the ocular surface (efficacy) without serious adverse events (safety).

  • 5 views
  • 24 Feb, 2022
  • 1 location
Effectiveness of a Positive Deviance Program in Reducing Childhood Undernutrition

Globally, childhood malnutrition remains a public health concern. Malnutrition can be diverse from undernutrition to overnutrition. A young child, primarily refers to those under the age of 5

Accepts healthy volunteers
  • 0 views
  • 24 May, 2022
  • 1 location
Talazoparib in Advanced Breast Cancer Patients With Homologous Recombinant Deficiency

Talazoparib has shown clinical efficacy in breast cancer patients with germline BRCA1 or BRCA2 mutations. Beyond BRCA1 and BRCA2 mutations, it is plausible that talazoparib may have activity in patients with homologous recombination defects (HRD).

  • 0 views
  • 07 Oct, 2022
  • 1 location
Functional Sucrase Deficiency in Short Bowel Syndrome Patients With Intestinal Failure

Short gut syndrome with intestinal failure patients may have decreased production of disaccharidases, like sucrase, an enzyme responsible for digesting sugar in foods. This can happen due to loss of bowel length from surgery or from loss of cellular function in the intestines due to use of parenteral nutrition intravenously. …

  • 0 views
  • 23 Mar, 2022
  • 1 location