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Found 487 clinical trials
A Phase I /IIa Study of RC88-ADC in Subjects With Advanced Malignant Solid Tumors

this study was to evaluate safety, tolerability, pharmacokinetic characteristics, and initial efficacy in malignant pleural mesothelioma and MSLN in advanced malignant solid tumors.

measurable disease
liver metastasis
metastasis
neutrophil count
  • 7 views
  • 03 May, 2022
  • 3 locations
Study of SYSA1801 in the Treatment of Claudin( CLDN) 18.2 Positive Advanced Malignant Solid Tumor

This is an open-label, dose escalation, dose expansion and extension cohort phase 1 study to evaluate the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of SYSA1801

filgrastim
tumor cells
measurable disease
granulocyte colony stimulating factor
cancer chemotherapy
  • 0 views
  • 01 Nov, 2021
  • 1 location
A Study of RC118 in Patients With Locally Advanced Unresectable or Metastatic Malignant Solid Tumors

In Phase I, This study will explore the tolerability and safety of RC118 in patients with locally advanced unresectable or metastatic malignant solid tumors with positive Claudin 18.2 expression

  • 0 views
  • 09 Apr, 2022
  • 1 location
Safety and Efficacy of CEA-targeted CAR-T for CEA-positive Advanced Malignant Solid Tumors

This study is a single-arm, open-label, dose-escalating + dose-expansion clinical study, aiming to evaluate the safety and efficacy of CEA-targeted CAR-T cell preparations, and to preliminarily observe the study drug in CEA-positive advanced malignant tumors. The pharmacokinetic characteristics of CAR-T cell preparations for the treatment of patients with CEA-positive advanced …

kidney function test
esophagus cancer
renal function
cyclophosphamide
pancreatic cancers
  • 0 views
  • 07 Oct, 2022
  • 1 location
Clinical Study of CEA-targeted CAR-T Therapy for CEA-positive Advanced Malignant Solid Tumors

This trial is an open-label, single-arm clinical study. The main purpose is to verify the safety and efficacy of CAR-T cell preparations in the treatment of CEA-positive advanced malignant tumors, and to obtain the recommended dose and infusion scheme of CAR-T cell preparations for the treatment of patients with CEA-positive …

cyclophosphamide
gastric cancer
cancer chemotherapy
cancer
kidney function test
  • 0 views
  • 04 Oct, 2022
  • 1 location
Research Trial to Study Safety of GEN1047 (DuoBody®-CD3xB7H4) in Participants With Malignant Solid Tumors

The drug that will be investigated in the study is an antibody, GEN1047. Since this is the first study of GEN1047 in humans, the main purpose is to evaluate safety. Besides safety, the study will determine the recommended GEN1047 dose to be tested in a larger group of participants and …

carcinoma
cancer of the ovary
ovarian cancer
measurable disease
cancer antigen 125
  • 1 views
  • 04 Oct, 2022
  • 6 locations
Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

This phase II trial studies the effect of avapritinib in treating malignant solid tumors that have a genetic change (mutation) in CKIT or PDGFRA and have spread to nearby tissue or lymph nodes

  • 0 views
  • 01 Jul, 2022
  • 1 location
Phase I Clinical Study of MBS301 in Treatment of HER2 Positive Recurrent or Metastatic Malignant Solid Tumor

This is a phase I study evaluating the safety and pharmacokinetics of MBS301 after intravenous administration in patients with HER-2 positive recurrent or metastatic malignant solid tumors

  • 9 views
  • 11 Mar, 2022
  • 1 location
A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors

This is a phase I clinical study to evaluate the safety and tolerability of CAR-T in patients with CEA-positive advanced malignant solid tumors, and to obtain the maximum tolerated dose of CAR-T

cyclophosphamide
gastric cancer
cancer chemotherapy
cancer
kidney function test
  • 0 views
  • 17 Jun, 2022
  • 1 location
A Clinical Study to Observe the Safety and Efficacy of ScTIL210 in the Treatment of Malignant Solid Tumors

An open-label, single-arm, single-dose escalation and multiple-dose expansion clinical study of cell therapy to observe and to evaluate the tolerance, the pharmacokinetic characteristics, the safety, and the efficacy of ScTIL210 in the treatment of malignant

  • 0 views
  • 25 Jul, 2021
  • 2 locations