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Found 484 clinical trials
A Phase 1 Study Exploring the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Select Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of INCB099280 in participants with select solid tumors

solid tumors
solid tumour
  • 22 views
  • 28 Oct, 2022
  • 13 locations
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Solid Tumors Malignancies

This clinical trial is evaluating a drug called BT8009 alone and in combination with nivolumab in participants with advanced solid tumors associated with Nectin-4 expression or in participants with advanced solid tumor malignancies having renal insufficiency. The main goals of this study are to: Find the recommended dose of BT8009 …

lung cancer
brain metastases
mammogram
diabetes
carcinoma
  • 109 views
  • 07 Oct, 2022
  • 20 locations
Role of Microbiome in the Realm of Immune-Checkpoint Inhibitor Induced GI Complications In Cancer Population

This trial studies the role of the gut microbiome and effectiveness of a fecal transplant on medication-induced gastrointestinal (GI) complications in patients with melanoma or genitourinary cancer. The gut microbiome (the bacteria and microorganisms that live in the digestive system) may affect whether or not someone develops colitis (inflammation of …

microbiota
gastrointestinal infections
genitourinary cancer
infliximab
endoscopy
  • 0 views
  • 28 Oct, 2022
  • 1 location
EXERCISING TOGETHER for Couples Coping With Cancer

The Exercising Together trial is a single-blind, parallel group, randomized controlled trial comparing 3 arms: Arm 1 (experimental): Exercising Together where couples perform partnered exercise in a supervised, group setting versus two comparator conditions where survivors and partners perform exercise routines separately in either a supervised group setting (Arm 2) …

metastasis
immunostimulant
Accepts healthy volunteers
group setting
endocrine therapy
  • 45 views
  • 03 Jun, 2022
  • 1 location
DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

thyroiditis
tumor cells
cholangiocarcinoma
mucinous adenocarcinoma
trophoblastic tumor
  • 6651 views
  • 22 Oct, 2022
  • 752 locations
CRESTONE: A Phase 2 Study of Seribantumab in Adult Patients With Neuregulin-1 (NRG1) Fusion Positive Locally Advanced or Metastatic Solid Tumors

This study is an open-label, international, multi-center, Phase 2 study in adult patients with recurrent, locally-advanced or metastatic solid tumors, which harbor the NRG1 gene fusion.

neutrophil count
platelet count
solid tumors
monoclonal antibodies
growth factor
  • 0 views
  • 18 Oct, 2022
  • 42 locations
Evaluation of SAR408701 in Japanese Patients With Advanced Malignant Solid Tumors

limiting toxicities (DLTs) to determine the recommended dose (RD) of SAR408701 in Japanese patients with advanced malignant solid tumors. Secondary Objectives: To characterize

solid tumor
  • 0 views
  • 04 Oct, 2022
  • 3 locations
A Clinical Study of 9MW2821 in Subjects With Advanced Malignant Solid Tumors

This study is a Phase 1/2, first-in-human, open-label, dose-escalation and cohort expansion study designed to characterize the safety, tolerability, pharmacokinetics, preliminary antitumor activity and immunogenicity of 9MW2821 administered by intravenous (IV) infusion.

  • 0 views
  • 02 Jul, 2022
  • 1 location
Ifetroban in Treating Patients With Malignant Solid Tumors at High Risk of Metastatic Recurrence

This pilot trial studies the side effects of ifetroban in treating patients with malignant solid tumors that are at high risk of coming back after treatment and spreading throughout the body

platelet count
serum bilirubin level
follicle stimulating hormone
systemic therapy
  • 63 views
  • 10 Jul, 2022
  • 1 location
A Phase I /IIa Study of RC88-ADC in Subjects With Advanced Malignant Solid Tumors

this study was to evaluate safety, tolerability, pharmacokinetic characteristics, and initial efficacy in malignant pleural mesothelioma and MSLN in advanced malignant solid tumors.

neutrophil count
metastasis
measurable disease
liver metastasis
  • 7 views
  • 03 May, 2022
  • 3 locations