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Found 483 clinical trials
Safety and Preliminary Effectiveness of BGB-A445 in Combination With Tislelizumab in Participants With Advanced Solid Tumors

The purpose of this study is to assess the safety and tolerability of BGB-A445 alone and in combination with tislelizumab in participants with advanced solid tumors; and to determine the maximum tolerated dose(s) (MTD) or maximum administered dose(s) (MAD) and recommended Phase 2 doses (RP2D) of BGB-A445 alone and in …

carcinoma
measurable disease
neutrophil count
liver metastasis
growth factor
  • 6 views
  • 07 Oct, 2022
  • 12 locations
A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

), advanced, relapsed or refractory programmed death-ligand 1 (PD-L1)-positive malignant solid tumor or other lymphoma (6 months to <18 years of age), relapsed or refractory classical

advanced malignant solid tumor
hodgkin's disease
advanced melanoma
measurable disease
serum pregnancy test
  • 525 views
  • 04 Oct, 2022
  • 18 locations
Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations

This BVD-523-ABC study builds on the safety and clinical activity experience of previous studies that have evaluated ulixertinib as a novel targeted cancer treatment in cohorts of patients with specific genetic alterations and tumor histologies that result in aberrant MAPK pathway signaling. Early clinical data have demonstrated anti-tumor activity with …

  • 0 views
  • 04 Oct, 2022
  • 23 locations
Approaches to Identify and Care for Individuals With Inherited Cancer Syndromes

This trial examines approaches to identify and care for individuals with inherited cancer syndrome. The purpose of this study is to offer no cost genetic testing to the general public. Researchers hope to learn the value of providing broad, public-wide testing for high risk cancer types (like hereditary breast and …

carcinoma
carcinoma in situ
primary cancer
Accepts healthy volunteers
BRCA2
  • 21 views
  • 14 Oct, 2022
  • 2 locations
Cancer Genetic Testing in Ethnic Populations

This clinical trial examines the integration of cancer genetic testing in various ethnic populations. Studying individuals and families at risk of cancer may help identify cancer genes and other persons at risk. The information from this study may provide an opportunity for cancer risk stratification and individualized screening in these …

nervous
cancer
  • 0 views
  • 07 Oct, 2022
  • 2 locations
A Phase 2 Open-Label Study of Sacituzumab Govitecan (IMMU-132) in Subjects With Metastatic Solid Tumors (TROPiCS-03)

The primary objective of this study is to assess the objective response rate (ORR) of sacituzumab govitecan-hziy in adult participants with metastatic solid tumors.

endometrial carcinoma
carcinoma
measurable disease
platinum-based chemotherapy
growth factor
  • 24 views
  • 24 Oct, 2022
  • 49 locations
Enhanced, EHR-facilitated Cancer Symptom Control Pragmatic Clinical Trial (E2C2)

This early phase I trial investigates enhanced, electronic health record (EHR)-facilitated cancer system control. Cancer and its treatment are often associated with severe, disabling symptoms that have been causally linked to diminished survival, increased healthcare utilization, degraded quality of life, unemployment, and non-adherence to recommended cancer treatments. Collaborative case management …

sleep problem
anxiety
depressed mood
depression
sleep disturbances
  • 31 views
  • 04 Oct, 2022
  • 1 location
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

brain stem tumor
neulasta
nervous
ulixertinib
beta-human chorionic gonadotropin
  • 1032 views
  • 25 Oct, 2022
  • 108 locations
Molecular Analysis for Therapy Choice (MATCH)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

sunitinib malate
dasatinib
brain metastases
gonadotropin
copanlisib
  • 6595 views
  • 20 Oct, 2022
  • 906 locations
INSPIRE-AYA: A Multicenter Interactive Survivorship Program to Improve Healthcare Resources for Adolescent and Young Adult (AYA) Cancer Survivors

This trial studies how well an interactive survivorship program works in improving healthcare resources in adolescent and young adult cancer survivors. By improving access to survivorship resources, health literacy, self-management skills, and support, an interactive survivorship program may help to improve adherence to adolescent and young adult healthcare guidelines and …

leukemia
lymphoma
chemotherapy regimen
cancer
cancer chemotherapy
  • 0 views
  • 24 Oct, 2022
  • 1 location