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Found 379 clinical trials
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A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor

This is an open-label, Phase 1b/2 study to determine the recommended dose of lucitanib in combination with nivolumab in patients with an advanced solid tumor (Phase 1b); followed by evaluation of the safety and efficacy of lucitanib and nivolumab in patients with an advanced gynecological solid tumor (Phase 2) and …

metastatic solid tumor
serum pregnancy test
nivolumab
measurable disease
  • 7 views
  • 05 Sep, 2021
  • 27 locations
None
Phase 1 Study of TPX-0022 a MET/CSF1R/SRC Inhibitor in Patients With Advanced Solid Tumors Harboring Genetic Alterations in MET

A phase 1, first-in-human, open-label study to determine the safety, tolerability, PK, and preliminary efficacy of the novel MET/CSF1R/SRC inhibitor TPX-0022 in adult subjects with advanced solid tumors harboring genetic alterations in MET. The study will proceed in three parts: a dose-escalation, a food effect, and dose-expansion.

metastasis
solid tumour
cns tumors
  • 10 views
  • 27 Jan, 2021
  • 20 locations
None
Self-Management Program and Survivorship Care Plan in Improving the Health of Cancer Survivors After Stem Cell Transplant

This phase III trial investigates health informatics and a self-management program for improving the health of cancer survivors after stem cell transplant. After transplant many survivors may feel stressed or may be unsure of what health care they need. A self-management program called "INSPIRE," along with a personalized survivorship care …

cancer
remission
  • 73 views
  • 17 Oct, 2021
  • 17 locations
None
Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations

This is an open-label, multicenter, multinational, Phase 2 basket study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in participants with HER (EGFR, HER2) mutation-positive solid tumors.

  • 83 views
  • 28 Sep, 2021
  • 73 locations
None
Deciphering Mechanisms Underlying Cancer Immunogenicity

solid tumors. The study will be conducted on a population of patients with local and/or metastatic malignant solid tumor and who are followed for their standard of care at the IUCT-O.

lung cancer
ovarian cancer
cancer
solid tumour
cin 3
  • 0 views
  • 26 Jan, 2021
  • 2 locations
None
Identifying and Caring for Individuals With Inherited Cancer Syndrome

This trial examines approaches to identify and care for individuals with inherited cancer syndrome. The purpose of this study is to offer no cost genetic testing to the general public. Researchers hope to learn the value of providing broad, public-wide testing for high risk cancer types (like hereditary breast and …

ductal carcinoma in situ
BRCA2
carcinoma
cancer
Accepts healthy volunteers
  • 13 views
  • 06 Oct, 2021
  • 2 locations
None
Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations

This BVD-523-ABC study builds on the safety and clinical activity experience of previous studies that have evaluated ulixertinib as a novel targeted cancer treatment in cohorts of patients with specific genetic alterations and tumor histologies that result in aberrant MAPK pathway signaling. Early clinical data have demonstrated anti-tumor activity with …

  • 0 views
  • 09 Sep, 2021
  • 21 locations
None
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphomas or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

bone marrow procedure
antineoplastic
cns tumor
cytotoxic chemotherapy
erdafitinib
  • 997 views
  • 17 Oct, 2021
  • 114 locations
None
A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion

This is a Phase I/II, open-label, multi-center, multi-national, dose escalation, single agent study to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor activity of zenocutuzumab (MCLA-128) in patients with solid tumors harboring an NRG1 fusion.

measurable disease
erbb2
direct bilirubin
cancer
neutrophil count
  • 427 views
  • 29 Jan, 2021
  • 30 locations
None
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

bone marrow procedure
hysterectomy
palliative radiation therapy
lhrh
trastuzumab
  • 6106 views
  • 17 Oct, 2021
  • 1028 locations