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Found 19 clinical trials
Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

Background NF1 is a genetic disease that causes tumors called atypical neurofibromas. These tumors, which arise from nerves, can cause serious medical problems. The only treatment is surgery. Researchers want to see if a drug called abemaciclib can help. Objective To find a safe, tolerable dose of abemaciclib for treating …

absolute neutrophil count
immunomodulators
dysplasia
plexiform neurofibroma
measurable disease
  • 0 views
  • 28 Jun, 2022
  • 1 location
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

Background Metastasis is the spread of cancer from one organ to a nonadjacent organ. It causes 90% of cancer deaths. No treatment specifically prevents or reduces metastasis. Researchers hope a new drug can help. It stops cancer cells from growing and spreading further and possibly shrink cancer lesions in distant …

metarrestin
x-rays
metastasis
renal function test
neutrophil count
  • 5 views
  • 19 Jun, 2022
  • 2 locations
Phase 1/2 Study of MRTX1719 in Solid Tumors With MTAP Deletion

This is a Phase 1/2, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.

measurable disease
  • 0 views
  • 09 Jun, 2022
  • 4 locations
B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

biologic therapy
biologic agent
stem cell infusion
iobenguane
solid tumor
  • 39 views
  • 11 May, 2022
  • 1 location
EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

biologic therapy
biologic agent
stem cell infusion
iobenguane
solid tumor
  • 484 views
  • 13 May, 2022
  • 1 location
A Study of APG-115 in Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Part 1 is the dose escalation of APG-115 in combination with label dose of pembrolizumab. Part 2 is phase II design of APG-115 at recommended phase 2 dose (RP2D) in combination with pembrolizumab in patients with programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) refractory/relapsed melanoma or NSCLC, lung …

programmed cell death protein 1
systemic therapy
LKB1
alopecia
lung adenocarcinoma
  • 34 views
  • 18 Jun, 2022
  • 19 locations
Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

This phase I trial studies the side effects of BO-112 when given together with nivolumab before surgery in treating patients with soft tissue sarcoma that can be removed by surgery (resectable). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere …

monoclonal antibodies
neutrophil count
sarcoma of the extremity
platelet count
leiomyosarcoma
  • 0 views
  • 13 May, 2022
  • 1 location
Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors

First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and

  • 5 views
  • 26 May, 2022
  • 8 locations
Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

peripheral nerve sheath tumor Malignant triton tumor Medullary thyroid cancer Mixed acinar adenocarcinoma Mixed acinar neuroendocrine carcinoma Myxoid

cns tumor
cancer
solid tumor
Accepts healthy volunteers
  • 36 views
  • 28 Jun, 2022
  • 1 location