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Found 24 clinical trials
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation (ORACLE)

The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctDNA test results are linked to clinical outcomes in order to demonstrate clinical validity for recurrence detection and …

lung carcinoma
lung cancer
gastric adenocarcinoma
endometrioid adenocarcinoma
clear cell adenocarcinoma
  • 07 Oct, 2022
  • 1 location
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

This research will have a significant impact on the overall management of those cancer patients and their family members who are at risk for hereditary cancer due to germline inactivation of BAP1. Our study will ultimately facilitate the development of novel screening, prevention and treatment strategies for these individuals with …

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
Peripheral T Cell Determinants of Response and Resistance to Pembrolizumab in Melanoma

This is a non-therapeutic study assessing peripheral T cell determinants of response and resistance to immunotherapy in patients with advanced melanoma.The hypothesis is that systemic T cells traffic into the tumor microenvironment (TME) can predict response and resistance to immunotherapy. These systemic tumor directed T cells can be defined by …

measurable disease
advanced melanoma
metastatic melanoma
  • 24 Nov, 2021
  • 1 location
Applicability of a Cellular Resolution Full-field OCT Image System for Pigmented and Non-pigmented Skin Tumors

The incidence of skin cancer has been continuously increasing over the past decades und the number of non melanoma skin cancer is well as melanoma is still going to increase. Invasive biopsy and histological examination represents the gold standard in diagnosis of benign and malignant skin tumors. However, novel technologies …

melanoma skin
malignant melanoma of skin
skin tumor
skin diseases
  • 15 Nov, 2021
  • 1 location