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Found 522 clinical trials
Pediatric Long-Term Follow-up and Rollover Study

A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.

dabrafenib
trametinib
  • 487 views
  • 06 May, 2022
  • 16 locations
Supramarginal Resection in Glioblastoma

Gliomas are the most common malignant brain tumor. Glioblastoma, WHO grade IV astrocytoma, is the most common subtype and unfortunately also the most aggressive subtype with median survival in

gross total resection
karnofsky performance status
supratentorial glioblastoma multiforme
brain tumor
malignant brain tumor
  • 0 views
  • 26 Oct, 2021
  • 20 locations
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

cns tumors
brain stem tumor
nitrosourea
vemurafenib
radiopharmaceutical therapy
  • 1032 views
  • 17 Jun, 2022
  • 105 locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

chemotherapy regimen
oophorectomy
afatinib
antiretroviral therapy
immunodeficiency
  • 6575 views
  • 13 Jun, 2022
  • 921 locations
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

lung cancer
tyrosine
breast cancer
NTRK
measurable disease
  • 162 views
  • 14 Jun, 2022
  • 129 locations
Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System (FIORELLA)

Primary central nervous system lymphomas are rare aggressive malignancies, usually treated in two steps: an induction phase (where a combination of chemotherapy is given) followed by a consolidation phase (where patients usually receive one of the following: whole-brain irradiation, chemotherapy supported by autologous stem-cell transplantation, other type of chemotherapy, or …

nervous
methotrexate
whole-brain radiotherapy
temozolomide
maintenance treatment
  • 0 views
  • 13 May, 2022
  • 35 locations
Infigratinib in Recurrent High-Grade Glioma Patients

This trial is an open-label, multicenter, Phase 0 trial that will enroll up to 20 participants with recurrent high-grade glioma with FGFR1 K656E or FGFR3 K650E mutation or FGFR3-TACC3

contrast-enhanced magnetic resonance imaging
renal function
FGFR1
recurrent malignant glioma
temozolomide
  • 0 views
  • 28 Jan, 2021
  • 3 locations
PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma (PRiME)

The primary goal of this prospective clinical trial is to evaluate the safety of PEP-CMV in patients with recurrent medulloblastoma and malignant glioma. Patients with histologically-proven

karnofsky performance status
montanide isa-51
MRI
brain mri
recurrent tumor
  • 22 views
  • 19 Jun, 2022
  • 1 location
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma

Childhood aggressive gliomas are rare brain tumors with very poor prognosis. Due to the tumor's location and infiltrative nature, surgical removal is not always possible, and even when resection

  • 0 views
  • 28 Sep, 2021
  • 1 location
Tumor Hypoxia and Proliferation in Patients With High-Grade Glioma

This is a pilot study to assess a new methodology developed for High Grade Glioma (HGG). FMISO PET (Fluoromisonidazole-PET) allows researchers to study whether tumor cells lack oxygen (hypoxia

vascular endothelial growth factor
vegf
EGFR
MRI
cancer
  • 0 views
  • 15 Apr, 2021
  • 1 location