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Found 515 clinical trials
The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier

multifocal disease and when long term and repetitive administration is required. This study seeks to investigate the efficacy of focused ultrasound. Patients with either low grade gliomas or

  • 0 views
  • 12 Sep, 2021
  • 1 location
Re-Irradiation of Progressive or Recurrent DIPG

This is a single-arm, non-randomized study of re-irradiation of diffuse intrinsic pontine glioma (DIPG)

  • 8 views
  • 24 Mar, 2022
  • 18 locations
A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) (PNOC020)

The primary objective will be to demonstrate the manufacturing feasibility and safety, and to determine the maximum tolerated dose (MTD) of RNA-LP vaccines in (Stratum 1) adult patients with newly diagnosed GBM (MGMT unmethylated).

  • 0 views
  • 15 May, 2022
  • 1 location
Therapeutic Targeting of Sex Differences in Pediatric Brain Tumor Glycolysis

The investigators will develop the concept of a sex-specific therapeutic intervention for gliomas that is based upon dietary carbohydrate restriction. The investigators will integrate

  • 7 views
  • 12 May, 2022
  • 1 location
Autologous Dendritic Cells, Metronomic Cyclophosphamide and Checkpoint Blockade in Children With Relapsed HGG

with relapsed high-grade gliomas. In addition, regulatory T cells are depleted by a short cycle of metronomic cyclophosphamide upfront of the vaccine in order to facilitate induction of immune

  • 0 views
  • 11 May, 2022
  • 1 location
Imaging Multiparametric/Multimodality for Lungcancer (IRMomics)

such as size, doubling time (if available), location, amount of enhancement and necrosis. Such approach has been proposed for glioma evaluation (Visually Accessible Rembrandt Images (VASARI)) but is

  • 2 views
  • 27 Jan, 2022
  • 1 location
Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Microdialysis permits sampling of molecules from the extracellular fluid, and has been utilized for studies of pharmacokinetics, and recovery of biomarkers. Gliomas remain incurable--in part due

  • 0 views
  • 28 Feb, 2022
  • 1 location
Clinical Safety Study on 5-Aminolevulinic Acid (5-ALA) in Children and Adolescents With Supratentorial Brain Tumors

In this prospective, open, single-armed, multicenter, phase II study for application of 5-ALA in children and adolescents with supratentorial brain tumors 80 patients will be investigated. Primary objective of the study is to determine the safety of 5-ALA for fluorescence-guided resections in children and adolescents with supratentorial, intra-axial brain tumors. …

  • 1 views
  • 09 May, 2022
A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

An open label single-arm clinical trial to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of HMPL-306 in advanced or metastatic solid tumors with IDH mutation.

  • 0 views
  • 13 Mar, 2022
  • 8 locations
Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors

This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific MTAP-deleted tumor types. The study drug, …

  • 0 views
  • 16 Jun, 2022
  • 4 locations