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Found 468 clinical trials
Comparison of Treatment Outcome of Cabergoline According to Target Prolactin Levels in Patients With Prolactinoma

The aim of this study is to investigate whether inhibition of serum prolactin levels below normal range during cabergoline administration may reduce the recurrence rate after drug withdrawal in patients with prolactinomas.

drug withdrawal
prolactinoma
prolactin
cabergoline
  • 90 views
  • 24 Jan, 2021
  • 1 location
Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery)

Hyponatremia is defined as sodium below the normal range of 135-145. Symptomatically, it can cause patients to experience a wide range of symptoms including lethargy, headache, nausea, vomiting and in severe cases coma and even death. The goal of this study is to prospectively compare two approaches to the postoperative …

cyst
prolactin
nausea
pituitary disorders
hormone secreting
  • 262 views
  • 23 Apr, 2021
  • 1 location
Child's Study of the Impact of PF Lesion on Motor Skills Language Cognitive Functioning and Social Cognition

One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized by transient postoperative mutism, dysarthria, behavioral, and affective disorders, as well as motor disorders. …

  • 0 views
  • 26 Jan, 2021
  • 5 locations
Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22

Central nervous system (CNS) malignancies are the second most common malignancy and the most common solid tumor of childhood, including adolescence. Annually in the United States, approximately 2,200 children are diagnosed with CNS malignancy and rates appear to be increasing. CNS tumors are the leading cause of death from solid …

oligodendroglioma
cetuximab
astrocytoma, anaplastic
erbitux
ct scan
  • 78 views
  • 01 May, 2021
  • 1 location
Seoul National University Pituitary Disease Cohort Study

The purpose of this study is to investigate the treatment and natural history of pituitary disease. We have a longstanding interest in pituitary disease including acromegaly, central diabetes insipidus, and nonfunctioning pituitary adenoma. We will continue to follow patients and recruit new patients for treatment and follow-up. Blood and pituitary …

nonfunctioning pituitary adenoma
diabetes
craniopharyngioma
cushing's syndrome
pituitary
  • 107 views
  • 24 Jan, 2021
  • 1 location
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells lentivirally transduced to express a B7H3-specific chimeric antigen receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor resection cavity or ventricular system …

dipg
supratentorial tumors
cns disease
central nervous system tumor
cancer chemotherapy
  • 8 views
  • 22 Mar, 2021
  • 1 location
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

This study will evaluate palbociclib in combination with chemotherapy (temozolomide with irinotecan and topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent or refractory solid tumors. The main purpose of this study is to evaluate the safety of palbociclib in combination with chemotherapy in order to estimate the …

renal function
dipg
renal function test
alopecia
central nervous system tumor
  • 113 views
  • 28 Apr, 2021
  • 64 locations
Long-Term Longitudinal QoL in Patients Undergoing EEA

This is a prospective longitudinal study to access postoperative 2-year quality of life in patients who undergo endonasal endoscopic approach surgeries of the skull base.

  • 0 views
  • 23 Jan, 2021
  • 1 location
Correlation Between SV2A Expression in Tumour Tissue and Efficacy of Levetiracetam in Glioma Patients With Epilepsy

The purpose of this study is to investigate the correlation of SV2A expression in surgically removed tumour and tumour-surrounding tissue of glioma patients suffering from epilepsy with their clinical response to levetiracetam.

oligodendroglioma
astrocytoma
partial seizure
glioblastoma multiforme
levetiracetam
  • 16 views
  • 07 Nov, 2020
  • 1 location
Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases

Background There are no standardized sets of tests to measure changes in neuropsychological functioning in patients treated for brain metastasis (cancer that has spread beyond the original site to the brain). Neuropsychological function has an important effect on quality of life and should be included when determining treatment options. Objectives …

metastasis
primary cancer
  • 20 views
  • 10 May, 2021
  • 1 location