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Found 468 clinical trials
Awake vs. Asleep Craniotomy for Non-eloquent Gliomas

This study protocol examines a comparison between local and general anesthesia (Awake vs. Asleep Craniotomy) in the removal of brain tumors that are in areas of the brain that do not directly

  • 25 Jan, 2021
  • 1 location
Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss

approved for the symptomatic treatment of pituitary adenomas that result in a hyperprolactinemic state (a brain tumor that results in milk leakage). The benefit of stopping milk leakage has also been

  • 01 Mar, 2021
  • 1 location
Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

microdialysis catheter) to recover an expanded range of potential biomarkers from the diseased human central nervous system in the context of surgery for brain tumors. This study is performed under an

  • 09 Mar, 2021
  • 1 location
PennPET Explorer Scanner Evaluation

radiotracers is useful for the diagnosis of various diseases, including cancer, brain diseases, infection, and heart or lung disease. The purpose of this study is to test a research PET machine called

  • 03 Feb, 2021
  • 1 location
MEK and Autophagy Inhibition in Metastatic/Locally Advanced Unresectable Neuroblastoma RAS (NRAS) Melanoma

and Jean Mulchey-Levy suggests that the activation of autophagy is a mechanism of resistance to BRAF and MEK inhibitors in RAS and RAF mutated cancers, such as melanoma, pediatric brain tumors and

  • 25 Jan, 2021
  • 5 locations
TAK-580 In Gliomas and Other Tumors

This research study is studying a drug TAK-580 (MLN2480) as a possible treatment a low-grade glioma that has not responded to other treatments. The name of the study drug involved in this study is: TAK-580 (MLN2480)

ejection fraction
measurable disease
  • 05 Apr, 2021
  • 13 locations
Manual Versus Targer-controll Infusion in Reduction of Awareness and Dreaming

This study compares manual total intravenous anesthesia (TIVA) and target-controll infusion (TCI) in reduction of awareness and dreaming, and the haemodynamical stability during operation. Half of patients will be anesthetized using manual TIVA and other half using TCI.

  • 30 Jan, 2021
  • 1 location
Adjuvant Dendritic Cell-immunotherapy Plus Temozolomide in Glioblastoma Patients

In this phase I/II trial, the primary objective is to determine overall and progression-free survival of patients with newly diagnosed glioblastoma when autologous Wilms' tumor 1 (WT1) messenger (m)RNA-loaded dendritic cell (DC) vaccination is added to adjuvant temozolomide maintenance treatment following (sub)total resection and temozolomide-based chemoradiation.

  • 28 Jan, 2021
  • 1 location
The Effects of Different Anesthetics on Functional Connectivity

This research is a prospective cohort study. The aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.

  • 26 Jan, 2021
  • 1 location
PSMA-specific CAR-T Cell Therapy

The purpose of this clinical trial is to assess the feasibility, safety and efficacy of PSMA-specific CAR-T cell therapy in patients with PSMA positive tumor. Another goal of the study is to learn more about the function of the PSMA CAR-T cells and their persistency in the patients.

  • 24 Jan, 2021
  • 4 locations