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Found 19 clinical trials
Tazemetostat in Malignant Peripheral Nerve Sheath Tumors

This phase 2, open label, single arm study will investigate the use of tazemetostat in patients with recurrent/refractory and/or metastatic malignant peripheral nerve sheath tumors.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Neoadjuvant Nivolumab Plus Ipilimumab for Newly Diagnosed Malignant Peripheral Nerve Sheath Tumor

Neurofibromatosis Type 1 (NF1) and newly diagnosed pre-malignant and malignant peripheral nerve sheath tumors (MPNST) for whom surgery for resection of tumor is indicated.

  • 0 views
  • 10 Jul, 2022
  • 1 location
DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

teratoma
metastatic malignancy
leuprolide
iv infusion
immunosuppression
  • 6651 views
  • 22 Oct, 2022
  • 752 locations
PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors (PLX3397)

The purpose of this study is to determine if treatment with PLX3397 and Sirolimus will be tolerated and result in shrinking of the cancer or stopping the cancer from growing. In the phase I portion, the maximum tolerate dose of the study drug will be determined. In the Phase II …

mpnst
small molecule
solid tumour
metastasis
neutrophil count
  • 0 views
  • 26 Jan, 2022
  • 4 locations
A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST)

The purpose of this study is to see whether the study drug ASTX727 is an effective treatment for people who have MPNST with a PCR2 mutation. ASTX727 is a combination of two drugs (cedazuridine and decitabine) that have been designed to target cancer cells with a PCR2 mutation and to …

  • 0 views
  • 07 Oct, 2022
  • 7 locations
Vaccine Therapy in Treating Patients With Malignant Peripheral Nerve Sheath Tumor That is Recurrent or Cannot Be Removed by Surgery

This phase I trial studies the side effects and the best dose of a vaccine therapy in treating patients with malignant peripheral nerve sheath tumor that cannot be removed by surgery

ct scan
measurable disease
absolute neutrophil count
tumor cells
  • 17 views
  • 04 Oct, 2022
  • 1 location
  • 0 views
  • 06 Oct, 2021
  • 1 location
A Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Pediatric and Adolescent-Young Adults Patients With High Risk Solid Tumors

This phase II trial investigates side effects and how well donor stem cell transplant after chemotherapy works in treating pediatric and adolescent-young adults with high-risk solid tumor that has come back (recurrent) or does not respond to treatment (refractory). Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit anti-thymocyte …

malignant peripheral nerve sheath tumor
stem cell transplantation
neuroectodermal tumor
etoposide
peripheral primitive neuroectodermal tumor
  • 0 views
  • 19 Oct, 2022
A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients

metastatic malignant peripheral nerve sheath tumors (MPNST), endometrial stromal sarcomas (ESS) and leiomyosarcoma (LMS). Participants will continue on study until disease progression or unacceptable side

mpnst
kidney function tests
metastasis
measurable disease
growth factor
  • 0 views
  • 18 Apr, 2022
  • 1 location
Phase I/II Trial of PLX3397 in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN)

Background Some people with cancer have solid tumors. Others have refractory leukemia. This doesn t go away after treatment. Researchers want to see if a drug called PLX3397 can shrink tumors or stop them from growing. Objectives To find the highest safe dose and side effects of PLX3397. To see …

malignant peripheral nerve sheath tumor
nitrosoureas
ejection fraction
measurable disease
corticosteroids
  • 48 views
  • 23 Oct, 2022
  • 1 location