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Found 17 clinical trials
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Tazemetostat in Malignant Peripheral Nerve Sheath Tumors

This phase 2, open label, single arm study will investigate the use of tazemetostat in patients with recurrent/refractory and/or metastatic malignant peripheral nerve sheath tumors.

  • 0 views
  • 24 Nov, 2021
  • 1 location
None
Neoadjuvant Nivolumab Plus Ipilimumab for Newly Diagnosed Malignant Peripheral Nerve Sheath Tumor

Neurofibromatosis Type 1 (NF1) and newly diagnosed pre-malignant and malignant peripheral nerve sheath tumors (MPNST) for whom surgery for resection of tumor is indicated.

  • 0 views
  • 19 Jun, 2021
  • 1 location
None
A Phase II Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma

function (GOF) mutation, including: epithelioid malignant peripheral nerve sheath tumor (EMPNST), extraskeletal myxoid chondrosarcoma (EMC), myoepithelial carcinoma, other INI1-negative malignant tumors

extraskeletal myxoid chondrosarcoma
beta human chorionic gonadotropin
solid tumour
growth factor
renal function tests
  • 2 views
  • 30 Sep, 2021
  • 25 locations
None
A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST)

The purpose of this study is to see whether the study drug ASTX727 is an effective treatment for people who have MPNST with a PCR2 mutation. ASTX727 is a combination of two drugs (cedazuridine and decitabine) that have been designed to target cancer cells with a PCR2 mutation and to …

  • 0 views
  • 27 Jun, 2021
  • 7 locations
None
PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors

The purpose of this study is to determine if treatment with PLX3397 and Sirolimus will be tolerated and result in shrinking of the cancer or stopping the cancer from growing. In the phase I portion, the maximum tolerate dose of the study drug will be determined. In the Phase II …

cancer
mpnst
platelet count
KIT
metastasis
  • 0 views
  • 09 Sep, 2021
  • 5 locations
None
Vaccine Therapy in Treating Patients With Malignant Peripheral Nerve Sheath Tumor That is Recurrent or Cannot Be Removed by Surgery

This phase I trial studies the side effects and the best dose of a vaccine therapy in treating patients with malignant peripheral nerve sheath tumor that cannot be removed by surgery

tumor cells
ct scan
measurable disease
absolute neutrophil count
  • 17 views
  • 25 Jun, 2021
  • 1 location
None
  • 0 views
  • 06 Oct, 2021
  • 1 location
None
Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor Telaglenastat Hydrochloride Anti-Cancer Treatment BeGIN Study

formation. Specific genetic mutations studied in this clinical trial are NF1 mutation for malignant peripheral nerve sheath tumors, and NF1, KEAP1/NRF2, or STK11/LKB1 mutation for other solid tumors

cancer
tumor cells
STK11
cancer treatment
LKB1
  • 2 views
  • 20 Nov, 2021
  • 15 locations
None
Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults

This phase II trial investigates side effects and how well donor stem cell transplant after chemotherapy works in treating pediatric and adolescent-young adults with high-risk solid tumor that has come back (recurrent) or does not respond to treatment (refractory). Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit anti-thymocyte …

bone marrow procedure
desmoplastic
primitive neuroectodermal tumor
peripheral primitive neuroectodermal tumor
malignant peripheral nerve sheath tumor
  • 0 views
  • 03 Mar, 2021
None
A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients

metastatic malignant peripheral nerve sheath tumors (MPNST), endometrial stromal sarcomas (ESS) and leiomyosarcoma (LMS). Participants will continue on study until disease progression or unacceptable side

  • 0 views
  • 04 Apr, 2021
  • 1 location