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Found 119 clinical trials
Featured trial
A Phase 1, Open-Label, Dose-Escalation, Safety and Tolerability Study of INCAGN02390 in Participants With Select Advanced Malignancies

The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of INCAGN02390 in participants with advanced malignancies. This investigational intervention treatment uses a single biological drug and is conducted in two parts. Part 1: INCAGN02390 at the protocol-defined starting dose administered every 2 weeks (Q2W), with …

cancer
advanced cancer
  • 226 views
  • 14 Dec, 2020
  • 4 locations
None
BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma

mesothelioma. The efficacy (whether the treatment works), safety and tolerability (side effects of treatment) of atezolizumab plus bevacizumab in combination with standard chemotherapy versus bevacizumab in

  • 107 views
  • 14 May, 2021
  • 54 locations
None
HMPL-453 in Advanced Malignant Mesothelioma

This is a phase II, single arm, multicenter and open-label study to evaluate the efficacy, safety and pharmacokinetic of HMPL-453 in patient with advanced Malignant Mesothelioma

  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma

A randomized Phase II trial to test whether the addition of intraoperative Photofrin-mediated photodynamic therapy to radical pleurectomy and post-operative chemo.improves OS in the treatment of patients with epithelioid MPM. Subjects assigned to the PDT arm will be given the photosensitizer prior to surgery . All subjects will receive maximal …

  • 22 views
  • 02 Jun, 2021
  • 2 locations
None
Pembrolizumab and Hypofractionated Stereotactic Radiotherapy in Patients With Malignant Pleural Mesothelioma

This is a multi-centre non-randomised open-label phase 1 trial of pembrolizumab given in combination with SBRT to part of a pleural-based lesion in patients with unresectable MPM. This study will recruit up to 18 patients whose MPM has progressed beyond first-line of palliative chemotherapy, with a platinum-based doublet, and now …

  • 0 views
  • 18 Apr, 2021
  • 4 locations
None
Feasibility of the LUM Imaging System for Peritoneal Surface Malignancies

, ovarian cancer and mesothelioma. This feasibility study consists of two parts: (a) a dose escalation phase to select the optimal dose followed by (b) enrollment of additional patients to develop the tumor

  • 0 views
  • 23 Sep, 2021
  • 1 location
None
Ibuprofen or Morphine in Treating Pain in Patients Undergoing Pleurodesis for Malignant Pleural Effusion

RATIONALE: Morphine and ibuprofen help lessen pain caused by pleurodesis. It is not yet known whether one drug is more effective than the other in lessening pleurodesis-related pain or whether the size of the chest drain tube affects pain. PURPOSE: This randomized clinical trial is studying ibuprofen to see how …

pleurodesis
  • 29 views
  • 07 Nov, 2020
  • 1 location
None
DENdritic Cell Immunotherapy for Mesothelioma

This study is to evaluate the overall survival (OS) rate (determined from the time of randomization in the study) of subjects who receive dendritic cell immunotherapy with MesoPher plus best supportive care (BSC) compared to BSC alone.

malignant mesothelioma
leukapheresis
chemotherapy regimen
folate antagonist
  • 40 views
  • 03 Feb, 2021
  • 5 locations
None
Nivolumab and Ipilimumab +/- UV1 Vaccination as Second Line Treatment in Patients With Malignant Mesothelioma

The objective of the study is to induce a meaningful progression-free survival benefit in patients with Malign Pleural Mesothelioma (MPM) after progression on first line standard platinum

ct scan
pemetrexed
total bilirubin
ipilimumab
nivolumab
  • 62 views
  • 02 Nov, 2021
  • 7 locations
None
Ph 2/3 Study in Subjects With MPM to Assess ADI-PEG 20 With Pemetrexed and Cisplatin

This is a study of ADI-PEG 20 (pegylated arginine deiminase), an arginine degrading enzyme versus placebo in patients with malignant pleural mesothelioma. Malignant pleural mesothelioma have

renal function
pemetrexed
pleural mesothelioma
arginine
chemotherapy regimen
  • 0 views
  • 16 Mar, 2021
  • 45 locations