Found 542 clinical trials
Phase I Study of Subventricular Zone Tumor Stem Cell Stereotactic Radiosurgery with Standard of Care Chemoradiation Therapy in newly Diagnosed Malignant Gliomas (WHO III and WHO IV Astrocytomas)
stereotactic radiosurgery will be more effective in destroying cancer stem cells than conventional radiation therapy, and (3) treatment will improve malignant glioma survival
- 4 views
- 11 Jun, 2020
- 1 location
A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur after Irradiation and Adjuvant Temozolomide Chemotherapy
The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma has recurred/progressed after radiation and temozolomide chemotherapy.
- 5 views
- 11 Jun, 2020
- 1 location
N0577 (CODEL) Phase III Intergroup Study of Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q co-deleted Anaplastic Glioma or Low Grade Glioma
People who are diagnosed with an oligodendroglioma and who haven't yet undergone treatment may be eligible. This study is comparing two standard regimens, radiation followed by PCV (Procarbazine, CCNU, and Vincristine) or radiation with temozolomide during and after radiation, to see which is better.
- 10 views
- 24 Jun, 2021
- 1 location
Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme (INTRAGO-II)
INTRAGO II resembles a multicentric, prospective, randomized, 2-arm, open-label clinical phase III trial which tests if the median progression-free survival (PFS) of patients with newly diagnosed glioblastoma multiforme (GBM) can be improved by the addition of intraoperative radiotherapy (IORT) to standard radiochemotherapy.
- 40 views
- 11 Jun, 2020
- 1 location
CG01-GBM Standard Chemotherapy versus Chemotherapy Chosen by Cancer Stem Cell Chemosensitivity Testing in the Management of Patients with Recurrent Glioblastoma Multiforme (GBM)
People who were previously diagnosed with glioblastoma (Grade IV) or Grade III glioma, and now have evidence that their tumor has come back or has started to grow again, and who would otherwise
- 117 views
- 24 Jun, 2021
- 1 location
RTOG-0834: Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial
RTOG-0834: Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial
- 112 views
- 08 Nov, 2020
- 1 location
ACNS0822: A Randomized, Phase II/III Study of Vorinotat (IND#71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab (IND#7921) and Local Irradiation Followed by Maintenance Bevacizumab and Temozolomide in Children with Newly Diagnosed High-Grade Gliomas
Maintenance Bevacizumab and Temozolomide in Children with Newly Diagnosed High-Grade Gliomas
- 66 views
- 08 Nov, 2020
- 1 location
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
anaplastic glioma or low grade glioma.
- 167 views
- 28 Jul, 2021
- 126 locations
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)
Grade Glioma aged 6 months to less than18 years of age at the time of initiation of therapy. Participants will be randomized to Arm A or Arm B. Arm A includes 68 weeks of single agent Vinblastine
- 0 views
- 24 Jan, 2021
- 24 locations