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Found 72 clinical trials
Using T-Cell Alloreactivity and Chimerism to Guide Immunosuppression Minimization in Intestinal Transplantation

their organ donor's bone marrow. The goal of this is to develop a post-transplant treatment strategy that controls rejection while reducing the high risk of infection and malignant disease associated

  • 0 views
  • 05 Jan, 2022
Digital Lifestyle Management for Weight Loss Control After Thyroidectomy in Thyroid Cancer Patients

many potential health problems, such as heart disease, diabetes, high blood pressure, and malignant disease. Recently, digital health care technology has been developed and applied for medical

  • 0 views
  • 25 Nov, 2021
  • 1 location
Distal Pancreatectomy Minimally Invasive or Open for Malignancy (DIPLOMA)

Objective: To compare MIDP with ODP regarding radical resection rate for pancreatic ductal adenocarcinoma (PDAC) in the pancreatic body or tail. Study design: A pan-European, randomized controlled, multicenter, patient-blinded non-inferiority trial. This protocol was designed according to the SPIRIT guidelines1. Pathologists judging the primary endpoint will be blinded for the …

pdac
cancer
  • 0 views
  • 28 Oct, 2021
  • 5 locations
HDM201 and Midostaurin (HDMM) in Relapsed/Refractory AML With FLT3mut and TP53wt. (HDMM)

This is a non-randomized prospective open-label single-arm clinical phase I trial investigating dose finding, feasibility and safety of the combined treatment of HDM201 and midostaurin in patients with relapsed/refractory acute myeloid leukemia (AML) with FLT3mut applying an accelerated titration design.

  • 0 views
  • 24 Mar, 2022
  • 1 location
Trial on Intraoperative Neuromonitoring (IONM) in Thyroid Cancer Surgery. (ACTION)

Scientific objectives: Primary objective: • To assess if the use of IONM can decrease the rates of temporary RLN palsy after thyroid cancer surgery Secondary objectives: To assess if the use of IONM can decrease permanent RLN palsy rates in patients with thyroid cancers To assess voice parameters in patients …

  • 0 views
  • 09 May, 2022
  • 1 location
Chronic Recurrent Multifocal Osteomyelitis - a Bacterial Cause?

Chronic recurrent multifocal osteomyelitis (CRMO) is an immune-mediated chronic inflammatory self- limiting disease with non-suppurative inflammation involving one or multiple bone foci. A bacterial etiology has not yet been proven, but the investigators hypothesize that CRMO is caused by chronic infection. Using existing knowledge of chronic infections combined with sensitive …

  • 471 views
  • 26 Feb, 2022
  • 1 location
PAlliative RAdioTherapy to Lung Cancer A Randomized Multicentre Phase III Study (PARAT)

The aim of this study is to examine if a shorter palliative radiotherapy fractionation scheme of 20 Gy / 4 F can reduce the early oesophageal toxicity compared to 30 Gy / 10 F in patients with lung cancer in performance status (PS) 0-2. Secondary aims are to examine the …

cancer
lung carcinoma
lung cancer
  • 2 views
  • 01 Feb, 2022
  • 1 location
The Role of Stereo-tActic BoDy RadIotherApy iN Oligo-Progressive MalignanT Disease (RADIANT)

Systemic therapy is the main treatment for patients with metastatic cancers. Oligo-progressionhas become a recognized entity for metastatic cancer and it is thought that a subset of cancer cells may develop heterogeneity and resistant clones while receiving systemic therapy. This results in overall tumor response but progression in metastatic sites. …

docetaxel
carcinoma
metastasis
primary cancer
breast cancer
  • 0 views
  • 23 Mar, 2022
  • 1 location
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

This study is designed to estimate the efficacy and toxicity of familial HLA mismatched bone marrow transplants in patients with non-malignant disease who are less than 21 years of age and could

acute chest syndrome
melphalan
reduced intensity conditioning
sickle cell disease
fludarabine
  • 18 views
  • 07 Mar, 2022
  • 2 locations
Clinical Impact of Dedicated MR Staging of Ovarian Cancer (MRStagingOC)

laparoscopy. However, diffusion-weighted magnetic resonance imaging (DW-MRI) has a very high sensitivity to detect small volume malignant disease, making it a potentially suitable staging tool. Aim of this

ovarian cancer stage
cancer of the ovary
cytoreductive surgery
  • 0 views
  • 27 Feb, 2022
  • 1 location