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Found 17193 clinical trials
APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma

This is a Phase Ib/II, open-label, multi-center study evaluating the safety, tolerability, efficacy, and PK/ Pharmacodynamics of APG-2575 in combination with Pd/DRd in patients with relapsed/refractory (RR) multiple myeloma (MM). The study consists of dose escalation and dose expansion phases. The study consists of will start with 2 arms noted …

platelet count
amyloid deposition
monoclonal protein
  • 07 Mar, 2022
  • 3 locations
Clinical and Genomic Predictors of Progression to Myeloma in Patients With Asymptomatic Monoclonal Gammopathies

The goal of this study is to find markers that may help to predict why some patients who have monoclonal gammopathy of unknown significance (MGUS) or smoldering multiple myeloma (SMM) that have no signs or symptoms of disease (asymptomatic) develop multiple myeloma, while others do not. Studying markers such as …

monoclonal antibodies
bone marrow plasma cells
multiple myeloma
monoclonal protein
  • 26 Jan, 2022
  • 1 location
Endodontic Microsurgery With the Use of L-PRF Block

This study evaluates the effect of leucocyte and platelet rich fibrin Block (L-PRF Block) during endodontic microsurgery (EMS) on patient's post-operative comfort and periapical bone healing in large peri-apical lesions.

  • 26 May, 2022
  • 1 location
Assessing Glutamine Metabolism in MGUS and Myeloma

The utilization of glutamine by the bone marrow plasma cells in MGUS and MM will be compared between each other after infusion of 13-carbon labelled glutamine.

bone marrow procedure
bone marrow plasma cells
measurable disease
  • 25 Mar, 2022
  • 1 location
Galeazzi Spine Surgery RegistryGaleazzi Spine Registry: Prospective Study for Clinical Monitoring (SPINEREG)

The SPINEREG study is a prospective observational registry. Eligible patients are subjects undergoing spine surgery at the participating institutions. Baseline health status and follow-up health status are recorded at pre-established steps.

spine surgery
  • 13 Feb, 2022
  • 1 location
Effect of Sleep Quality on Hematopoietic Cell Transplant Patient Outcomes

This randomized, controlled study will compare Mindfulness Awareness Practices for Insomnia (MAP-I) to sleep health education (SHE) in subjects receiving autologous hematopoietic cell transplant for multiple myeloma.

  • 27 Sep, 2021
  • 1 location
Examination of Vertebroplasty in Addition to Regular Treatment of Patients With Multiple Myeloma.

Patients with newly diagnosed or known multiple myeloma with newly diagnosed vertebral lesion(s) will be invited to participate in a cross-sectoral randomized controlled trial. The trial will compare two groups of patients which either receive regular medical treatment of their vertebral lesion(s) or vertebroplasty in addition to regular medical treatment. …

  • 29 Sep, 2021
  • 1 location
Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant

This phase I/II trial studies the side effects and best dose of gene therapy in treating patients with human immunodeficiency virus (HIV)-related lymphoma that did not respond to therapy or came back after an original response receiving stem cell transplant. In gene therapy, small stretches of deoxyribonucleic acid (DNA) called …

follicular lymphoma
HIV Vaccine
  • 08 Jul, 2022
  • 4 locations
Pediatric Orthopaedic Implant Safety & Efficacy (IS&E)

Implant devices are important tools - their use is essential across a number of orthopaedic indications, including hip conditions, trauma and limb deformity. Given the vital role fixation devices play in maintaining alignment, promoting healthy bone healing and preventing joint degeneration, it is essential to understand the expected lifetime outcomes …

Accepts healthy volunteers
  • 13 May, 2022
  • 1 location
Cardiovascular Disease Discovery Protocol

Background Researchers are interested in studying individuals who have known or suspected metabolic or genetic diseases that put them at a high risk for heart diseases or diseases of their blood vessels. To improve the results of the study, both affected and nonaffected individuals will be asked to provide blood …

ct scan
positron emission tomography
cardiovascular disease
  • 16 Sep, 2022
  • 1 location