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Found 44 clinical trials
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8-week of PS128 RCT in Patients With Major Depressive Disorder

(DSM-V) criteria of major depressive episode in recent 2 years; Psychotropics including antidepressants, antipsychotics and hypnotics have been kept unchanged for at least 1 months. The exclusion

antidepressants
major depressive disorder
depressive symptoms
schizophrenia
major depressive disorder, single episode
  • 2 views
  • 24 Jan, 2021
  • 1 location
None
The Effect of Celecoxib on Neuroinflammation in MDD

found that MDD patients in a current major depressive episode (MDE) had significantly higher TSPO binding in the prefrontal cortex (PFC), anterior cingulate cortex (ACC) and insula, relative to healthy

  • 0 views
  • 10 Jun, 2021
  • 1 location
None
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)

The goal of the study is to conduct a comparative randomized trial of electroconvulsive therapy (ECT) vs. ketamine for patients with treatment resistant depression (TRD) in a real world setting with patient reported outcomes as primary and secondary outcome measures.

depressed mood
antidepressants
depressive symptoms
major depressive disorder
depressive disorder
  • 1848 views
  • 29 Aug, 2021
  • 5 locations
None
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

Purpose: To determine whether COX-1 and COX-2 are detectable in the brains of individuals with MDD experiencing a major depressive episode (MDE). Endpoints

depressed mood
scid
fluoxetine
anxiety
Accepts healthy volunteers
  • 0 views
  • 10 Oct, 2021
  • 1 location
None
Desvenlafaxine Succinate (DVS) for Major Depressive Disorder (MDD) in Midlife Men and Women

The main objective of this study is to characterize a range of brain activation symptoms associated with depression and response to treatment in midlife men and women with MDD, using MRI and functional MRI. Moreover, in the female sub-group, the investigators will examine whether these brain activation symptoms are related …

major depressive disorder
desvenlafaxine
depression
functional magnetic resonance imaging
  • 74 views
  • 07 Nov, 2020
  • 1 location
None
Duloxetine for Major Depression in Peri-/Postmenopausal Women

The main objective of this study is to characterize a range of brain activation symptoms associated with major depression in peri- and post-menopausal women. Also, assessing brain activation before and after the treatment might help to uncover some mechanisms associated with the pathophysiology of depression and menopause.

duloxetine
depressive episode
major depressive disorder
major depressive disorder, single episode
depression
  • 49 views
  • 07 Nov, 2020
  • 1 location
None
Development and Evaluation of Culturally Adapted CBT for South Asian Canadians

As CBT was developed for persons from North America and European background it needs to be adapted for persons from non-Western cultures. This mixed methods study proposes a culturally adapted Cognitive Behavioural Therapy (CA-CBT) model for Canadians of South Asian origin. Beginning with a participatory/qualitative research approach, common themes amongst …

depressed mood
anxiety
behavior therapy
  • 0 views
  • 09 Aug, 2021
  • 3 locations
None
Efficacy of Edupression.Com in Depressive Patients

The aim of the study is to investigate the efficacy and adherence of the digital self-help programme edupression.com.

  • 0 views
  • 07 May, 2021
  • 1 location
None
Psychoeducation Programmes - Patients With Bipolar Disorder

This is a controlled, randomized, prospective, open-label, non-inferiority trial lasting 12 months. The effectiveness of using a psychoeducational smartphone application (SIMPLe) will be compared to the effectiveness of face-to-face group psychoeducation.

  • 0 views
  • 11 Mar, 2021
  • 10 locations
None
Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression

We propose a clinical study of medial forebrain bundle DBS as a treatment in 10 patients with treatment refractory depression (TRD). Data from the University of Bonn indicates that surgical lesions of the medical forebrain bundle can produce therapeutic benefits in patients with depressive disorders, and suggest that DBS at …

antidepressants
brain stimulation
major depressive disorder
depressive disorder
depression
  • 247 views
  • 29 Sep, 2021
  • 1 location