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Found 44 clinical trials
Featured trial
Outpatient study for an investigational medication for depression

Outpatient study for an investigational medication for depression

  • 1152 views
  • 08 Nov, 2020
  • 1 location
None
Minocycline as Adjunctive Treatment for Treatment Resistant Depression

treatment approach. This study is a 12 week, double-blind, placebo-controlled trial of minocycline as add-on treatment for patients suffering from a major depressive episode who have failed to

bupropion
antidepressants
citalopram
venlafaxine
psychosis
  • 20 views
  • 22 Aug, 2021
  • 1 location
None
COG-PSYCHO : Social Cognition and Psychotic Characteristics: Genetic and Phenomic Approach

Bipolar disorder (BD), schizophrenia and depression can feature cognitive impairment, especially in social cognition (SC). According to previous studies, some genes from the oxytocin and dopamine pathways may be involved SC performance. Our endophenotype approach aimed to demonstrate that SC deficits are more severe in schizophrenia and BD or depression …

  • 18 views
  • 24 Jun, 2021
  • 1 location
None
Cerebral Neuroinflammation During Major Depressive Episode

the investigators make the following assumptions: 1) neuroinflammation in MDD can be measured by the [18 F ] DPA- 714 ; 2) it is accompanied by anatomical and functional changes in the frontal subcortical loops, strongly involved in MDD ; 3) neuroinflammation in patients might be a biomarker related to …

remission
antidepressants
blood tests
Accepts healthy volunteers
depressive episode
  • 7 views
  • 06 Nov, 2021
  • 4 locations
None
Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode

This study aims at investigating if adjunctive buprenorphine at low dose to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode, and at determining the

depression
depressed mood
analgesic
  • 0 views
  • 25 Jul, 2021
  • 11 locations
None
Social Stress and Suicide

Only vulnerable patients, when facing environmental stressors, attempt or commit suicide. Previous research demonstrated that suicide attempters usually misunderstand the social context and show impairments in decision making. Heart activity, endocrine and inflammatory response to stress were related with these features. For that, suicide attempters, in a context of social …

  • 0 views
  • 02 Feb, 2021
  • 1 location
None
Predict MDE Outcomes After MST

This trial attempts to explore the treatment outcome of magnetic seizure therapy (MST) for major depressive episode. Half of the participants will receive MST, while the other half will receive

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Comparing Uni- and Bi-lateral TBS in Major Depression

Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS) is a very promising new treatment for major depression that allows a 15-fold reduction in duration of daily sessions. However, no large scale naturalistic study has assessed the superiority of bilateral TBS …

  • 6 views
  • 25 Jan, 2021
  • 1 location
None
Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study

clinical, imaging, EEG, and molecular data across 8 sites to predict treatment outcome for patients experiencing a major depressive episode (MDE).

brexpiprazole
depression
antidepressants
major depressive disorder, single episode
citalopram
  • 81 views
  • 03 May, 2021
  • 6 locations
None
Patient-oriented Randomized Pragmatic Feasibility Trial With rTMS in Depression and Anxiety

This trial compares intermittent theta-burst stimulation (iTBS) to low frequency repetitive transcranial magnetic stimulation (LFR) in regards to depression and anxiety outcomes in 100 patients with treatment resistant depression (TRD).

  • 0 views
  • 15 Nov, 2021
  • 1 location