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Found 464 clinical trials
A Double-blind, Randomized, Psychoactive Placebo-controlled, Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (28 mg, 56 mg and 84 mg) of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Subjects Assessed to be at Imminent Risk for Suicide

(oral midazolam) in rapidly reducing the symptoms of major depressive disorder (MDD) including suicidal ideation in participants 12 to less than 18 years of age who are assessed to be at imminent risk

cognitive therapy
fluoxetine
suicide
sertraline
psychiatric disorder
  • 2406 views
  • 19 Aug, 2022
  • 33 locations
Appalachian Mind Health Initiative

) in rural West Virginia (WV) will help improve treatment of patients with Major Depressive Disorder (MDD). WV is one of the most rural states in America and mental health treatment resources are low

  • 13 views
  • 24 Nov, 2021
  • 12 locations
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine

  • 258 views
  • 10 May, 2022
  • 76 locations
Blended Care Versus Face-to-Face Therapy for Depression (BLENDED)

Depression is a severe mental disorder that affects 5-7% of Belgians each year. Unfortunately, many individuals with depression do not seek professional help, and if they do seek professional help, waiting lists for psychotherapy are typically very long. To help resolve this problem, this study aims to investigate whether blended …

psychotic symptoms
cognitive therapy
psychiatric disorder
behavior modification
psychotherapy
  • 10 views
  • 03 Mar, 2022
  • 5 locations
The Effects of Videogames on Depression Symptoms and Brain Dynamics

The purpose of the study is to evaluate the effects of a game-based digital-therapeutics (DTx) medical software device on the symptoms of depression in adults with confirmed major depressive

Accepts healthy volunteers
  • 0 views
  • 11 Aug, 2022
  • 2 locations
Enhanced Measurement-Based Care Effectiveness for Depression (EMBED) Study:A Cluster Randomized Controlled Trial of Enhanced Versus Standard Measurement-Based Care Implementation for Depression (EMBED)

MBC results in improved outcomes for patients with major depressive disorder (MDD), there are barriers to its broad implementation in clinical settings. The use of "enhanced" MBC (eMBC), with mobile

  • 0 views
  • 14 Sep, 2022
  • 1 location
A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

participants with major depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or

hdrs
fluoxetine
depressive episode
antidepressants
venlafaxine
  • 1390 views
  • 14 Jul, 2022
  • 123 locations
  • 217 views
  • 19 Sep, 2022
  • 74 locations
Computerized Detection and Internet-based Treatment of Common Mental Disorders Among College Students in Two Latin American LMICs

The aim is to evaluate short term and longer term treatment effects of internet-delivered cognitive behavioral therapy compared to treatment as usual for college students with anxiety and/or depression in low-middle income countries of Latin America.

  • 0 views
  • 20 Aug, 2022
  • 1 location
Chinese Longitudinal and Systematic Study of Bioplar Disorder (CLASS-BD)

Affective disorders (mainly including major depressive disorder and bipolar disorder) are common, chronic and highly disabling mental disorders, which lack of objective biological markers. It is

Accepts healthy volunteers
  • 0 views
  • 09 Aug, 2022
  • 1 location