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Found 518 clinical trials
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Molecular Diagnosis of Idiopathic Interstitial Pneumonias: a Prospective Study

of gene expression profiles on SLBs. Individual genes expression levels will be determined by RT-PCR. The diagnosis will be determined by MDD and further validated by prospective follow-up of

hypertension
pulmonary disease
idiopathic pulmonary fibrosis
ct scan
chest ct
  • 18 views
  • 25 Oct, 2021
  • 1 location
None
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.

mania
bipolar disorder
lithium
suicidal
depressive episode
  • 394 views
  • 12 Jul, 2021
  • 1 location
None
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

, schizophrenia, and substance abuse. Many of these sex differences emerge during or shortly after puberty and are maintained until the 5th-6th decade of life. For example, the two-fold greater risk of unipolar

Accepts healthy volunteers
  • 7 views
  • 15 Oct, 2021
  • 1 location
None
Prospective Study of the Prognostic Value of New Markers in Adults With ALK-positive Large Anaplastic Lymphoma

The study aims to evaluate the prognostic value on the complete metabolic response rate (MCR), the incidence of relapse / progression, the Progression Free Survival (PFS) and the Overall Survival (OS). at diagnosis after the first cycle of CHOEP (early evaluation) at the end of treatment

  • 4 views
  • 06 Aug, 2021
  • 21 locations
None
Fatigue a Long COVID-19 Symptom Substudy of FSC19-KN Trial

Prospective, controlled follow-up observation of SARS-CoV-2 positive patients with regard to the aspect of fatigue (cognitive / motor) and psychological disorders in the areas of anxiety, depression and somatization.

  • 0 views
  • 04 Jun, 2021
  • 1 location
None
A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

With the development of molecular biology and precise medical treatment, new challenges have been raised in the diagnosis and treatment of non-Hodgkin lymphoma (NHL) in children. In recent years, the criteria for clinical staging and efficacy evaluation of NHL in children have been updated. Recent clinical studies of COG in …

PTEN
lymphoblastic lymphoma
hodgkin's disease
cancer
  • 5 views
  • 23 Jan, 2021
  • 1 location
None
Implementation of Brief Dynamic Interpersonal Therapy at the VA

The goal of the proposed project is to collect data from clinician files and the electronic medical record to describe the clinical implementation of Brief Dynamic Interpersonal Therapy (DIT), an individual psychotherapy for depression and anxiety, at the VA through psychology staff and trainees between 2012-present.

anxiety
depressed mood
depression
psychotherapy
  • 45 views
  • 10 Apr, 2021
  • 1 location
None
Cardiac Markers in Depressed Patients With Coronary Heart Disease

Depression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression. This study will investigate the cardiac risk markers that are associated with depression symptoms that remain despite treatment, and …

  • 0 views
  • 27 Jan, 2021
  • 1 location
None
Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study

The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. We focus on cognitive network connectivity as a predictive biomarker of the clinical effect of TMS, and as a response biomarker of …

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Musculoskeletal Nociceptive Pain in Participants With Neuromuscular Disorders

The primary aim is to characterize the prevalence, severity and quality of musculoskeletal nociceptive pain in adult patients with neuromuscular disorders (NMD). The secondary objectives are to evaluate whether severity and distribution of muscle pain is associated with muscle function, and to assess whether muscle pain is associated with alterations …

exercise tests
dyspnea
  • 0 views
  • 18 Jun, 2021
  • 1 location