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Found 508 clinical trials
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.

mania
depression
depressive episode
bipolar disorder
lithium
  • 394 views
  • 12 Jul, 2021
  • 1 location
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

, schizophrenia, and substance abuse. Many of these sex differences emerge during or shortly after puberty and are maintained until the 5th-6th decade of life. For example, the two-fold greater risk of unipolar

  • 7 views
  • 12 Sep, 2021
  • 1 location
Prospective Study of the Prognostic Value of New Markers in Adults With ALK-positive Large Anaplastic Lymphoma

The study aims to evaluate the prognostic value on the complete metabolic response rate (MCR), the incidence of relapse / progression, the Progression Free Survival (PFS) and the Overall Survival (OS). at diagnosis after the first cycle of CHOEP (early evaluation) at the end of treatment

  • 4 views
  • 06 Aug, 2021
  • 21 locations
A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

With the development of molecular biology and precise medical treatment, new challenges have been raised in the diagnosis and treatment of non-Hodgkin lymphoma (NHL) in children. In recent years, the criteria for clinical staging and efficacy evaluation of NHL in children have been updated. Recent clinical studies of COG in …

lymphoblastic lymphoma
hodgkin's disease
PTEN
cancer
  • 5 views
  • 23 Jan, 2021
  • 1 location
Fatigue a Long COVID-19 Symptom Substudy of FSC19-KN Trial

Prospective, controlled follow-up observation of SARS-CoV-2 positive patients with regard to the aspect of fatigue (cognitive / motor) and psychological disorders in the areas of anxiety, depression and somatization.

  • 0 views
  • 04 Jun, 2021
  • 1 location
Implementation of Brief Dynamic Interpersonal Therapy at the VA

The goal of the proposed project is to collect data from clinician files and the electronic medical record to describe the clinical implementation of Brief Dynamic Interpersonal Therapy (DIT), an individual psychotherapy for depression and anxiety, at the VA through psychology staff and trainees between 2012-present.

depressed mood
anxiety
depression
psychotherapy
  • 45 views
  • 10 Apr, 2021
  • 1 location
Effect of Electroconvulsive Therapy on Retinal Nerve Fiber Layer Thickness in Depression

The aim of this study is to investigate the changes in the retinal nerve fiber layer thickness of the patients with depression who received electroconvulsive therapy by means of optical coherence tomography.

depressed mood
major depressive disorder
electroconvulsive therapy
  • 2 views
  • 03 Feb, 2021
  • 2 locations
Cardiac Markers in Depressed Patients With Coronary Heart Disease

Depression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression. This study will investigate the cardiac risk markers that are associated with depression symptoms that remain despite treatment, and …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study

The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. We focus on cognitive network connectivity as a predictive biomarker of the clinical effect of TMS, and as a response biomarker of …

  • 0 views
  • 26 Jan, 2021
  • 1 location
The Effect of CPAP Treatment on Cognitive Functions Anxiety and Affective Symptoms

Long term, prospective study of continuous positive airway pressure treatment influence on cognitive functions in patients with obstructive sleep apnea syndrome.

continuous positive airway pressure
apnea-hypopnea index
  • 1 views
  • 23 Jul, 2021
  • 1 location