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Found 527 clinical trials
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A Longitudinal Study of Inflammatory Pathways in Depression

Suicide accounts for at least 1 million deaths globally each year. This is likely a significant underestimate, because suicide is under-reported in many countries. In the US, over 42,000 people die from suicide annually. Despite increased focus on identification and treatment, the rate of suicide has increased steadily over the …

suicide
depression
suicidal
scid
  • 469 views
  • 05 Apr, 2021
  • 1 location
None
Pain Reward Attention and Neurocircuitry: Biomarkers of Suicidality

The ultimate aim of this study is to identify a biomarker of suicide risk in MDD by measuring the "hedonic spectrum" (pain and reward responsivity), attention and its associated brain structures

suicide
depressive episode
depressed mood
Accepts healthy volunteers
depression
  • 420 views
  • 07 Oct, 2021
  • 1 location
None
MicroRNA Correlates of Childhood Maltreatment and Suicidality

This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA [MiRNA]) levels. miRNAs are a type of RNA (genetic material that is translated into …

depression
depressed mood
  • 20 views
  • 09 Jul, 2021
  • 2 locations
None
Cortical Excitability and Inhibition in Children and Adolescents With Major Depressive Disorder

This study is being done to determine whether measures of brain activity (known as cortical excitability and inhibition) collected by Transcranial Magnetic Stimulation (TMS) are different in children and adolescents with depression and children and adolescents that do not have depression.

depressive disorder
transcranial magnetic stimulation
  • 100 views
  • 07 Nov, 2020
  • 1 location
None
The Gut Microbiota of Bipolar and Depression

elucidating the complement of the gut microbiome community for individuals with Major Depressive disorder (MDD) and Bipolar disorder (BD) relative to controls, and test for relationships with symptoms.

bipolar disorder
depressive disorder
depressed mood
psychiatric treatment
depression
  • 283 views
  • 27 Aug, 2021
  • 1 location
None
Imaging mGluR5 and Synaptic Density in Psychiatric Disorders

This research study is designed to look at the involvement of the glutamate system and synaptic density in depression and bipolar disorder. Each participant will undergo a screening appointment to determine study eligibility. Thereafter, the study will take 2 or 3 visits depending on schedule availability and will consist of …

bipolar disorder
depressive disorder
psychiatric disorder
major depressive disorder
functional magnetic resonance imaging
  • 91 views
  • 06 Mar, 2021
  • 1 location
None
A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women

Pregnant women who are taking lamotrigine will be evaluated monthly during pregnancy including a clinical evaluation and a blood draw for lamotrigine levels at each visit. Based on the Therapeutic Drug Monitoring protocol, participant's lamotrigine dosing will be adjusted as needed based on participant's blood levels compared to the reference …

bipolar disorder
lamotrigine
depressive disorder
psychiatric disorder
schizoaffective disorder
  • 20 views
  • 27 Jan, 2021
  • 1 location
None
  • 0 views
  • 27 Jan, 2021
  • 1 location
None
A Study of Pregnant and Postpartum Women With and Without Mood Disorders

This study is looking at genetic, biological, and environmental causes and how all three may work together to cause postpartum mood episodes. Participants will have psychiatric histories taken and will be monitored throughout pregnancy and during the postpartum period for the development of depressive or other mood episodes. Biological measures, …

mood disorder
Accepts healthy volunteers
  • 240 views
  • 16 Oct, 2021
  • 1 location
None
Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders

bipolar disorder
mood disorder
depressive disorder
major depressive disorder
  • 29 views
  • 22 Jan, 2021