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Found 465 clinical trials
Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders

mood disorder
major depressive disorder
bipolar disorder
depressive disorder
  • 29 views
  • 22 Jan, 2021
A Study of Pregnant and Postpartum Women With and Without Mood Disorders

This study is looking at genetic, biological, and environmental causes and how all three may work together to cause postpartum mood episodes. Participants will have psychiatric histories taken and will be monitored throughout pregnancy and during the postpartum period for the development of depressive or other mood episodes. Biological measures, …

mood disorder
Accepts healthy volunteers
  • 432 views
  • 12 Feb, 2022
  • 1 location
A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders (GDKet)

This study aims to openly test the long-term safety, tolerability and effectiveness of repeated administration of IV, nasal spray and oral ketamine for treatment-resistant mood disorders.

bipolar disorder
ketamine
depressive disorder
electroconvulsive therapy
nasal spray
  • 167 views
  • 24 Feb, 2022
  • 1 location
Sensor-based Characterization of Depression (SENSCODE)

This is a longitudinal study where individual with Major Depressive Disorder (MDD) will be monitored for 12 weeks. The study aims to develop an objective, sensor-based, algorithm able to detect

antidepressants
hdrs
depressed mood
depressive disorder
depression
  • 0 views
  • 04 Mar, 2022
A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With Systemic ALK(+) ALCL

With the development of molecular biology and precise medical treatment, new challenges have been raised in the diagnosis and treatment of non-Hodgkin lymphoma (NHL) in children. In recent years, the criteria for clinical staging and efficacy evaluation of NHL in children have been updated. Studies in Germany and the United …

anaplastic large cell lymphoma
lymphoma
hodgkin's disease
  • 3 views
  • 28 May, 2022
  • 1 location
ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators

The investigators propose a test of causality by examining a cohort of patients undergoing deep brain stimulation (DBS) within the ventral striatum. The investigators will examine behavior on and off stimulation across a range of tasks that index different forms of impulsivity. Patients will be studied in both the ON …

aversion
brain stimulation
deep brain stimulation
  • 64 views
  • 18 Apr, 2022
  • 1 location
Brain-Based Biomarkers in Response to TMS in MDD

The overarching goal of this research program is to elucidate causal and directional neural network- level abnormalities in depression, and how they are modulated by an individually-tailored, circuit-directed intervention. By using concurrent TMS and EEG, the investigators can overcome a major limitation of EEG - the inability to demonstrate causality. …

antidepressants
depressed mood
seizure
depression
transcranial magnetic stimulation
  • 70 views
  • 23 Feb, 2022
  • 1 location
Pharmacogenetics of Antidepressant-Induced Disinhibition (PGx-AID)

depressive disorder (MDD), anxiety disorders and/or obsessive-compulsive disorder (OCD) that could be used clinically to reduce the incidence of this adverse event and improve health outcomes.

depressive disorder
selective serotonin reuptake inhibitors
obsessive compulsive disorder
serotonin reuptake inhibitors
antidepressants
  • 199 views
  • 07 Feb, 2022
  • 1 location
Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK) (UnMASCK)

Mood disorders are associated with significant financial and health costs for the United States, partially due to cognitive problems in these patients that can worsen disease course and impair treatment response. This study proposes to use smartphone-based technology to monitor cognitive problems in patients with mood disorders by linking brain …

affective symptoms
mood disorder
bipolar disorder
depressive disorder
psychiatric disorder
  • 20 views
  • 24 Mar, 2022
  • 1 location
Naturalistic Study of Ketamine in the Treatment of Depression

This study aims to examine the effect of ketamine in decreasing the risk of suicide in patients with depression and its effectiveness as an antidepressant agent.

valproic acid
ketamine
depressive disorder
depression
lamotrigine
  • 0 views
  • 10 Mar, 2022
  • 1 location