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Found 465 clinical trials
Long-term Study With Trazodone Once-a-Day

The aim of the present observational study is to assess the clinical response, functional impairment and quality of life in outpatients with Major Depressive Disorder who demonstrated an initial

psychiatric disorder
major depressive disorder
  • 0 views
  • 30 Oct, 2021
  • 1 location
The Neurobiological Fundaments of Depression and Its Relief Through Neurostimulation Treatments

The study will apply state of the art radiology through advanced magnetic resonance imaging (MRI) techniques to investigate structural and functional brain effects of electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS).

Accepts healthy volunteers
  • 0 views
  • 02 Dec, 2021
  • 1 location
Cortical Excitability and Inhibition in Children and Adolescents With Major Depressive Disorder

This study is being done to determine whether measures of brain activity (known as cortical excitability and inhibition) collected by Transcranial Magnetic Stimulation (TMS) are different in children and adolescents with depression and children and adolescents that do not have depression.

depressive disorder
transcranial magnetic stimulation
  • 114 views
  • 07 Nov, 2020
  • 1 location
A Longitudinal Study of Inflammatory Pathways in Depression

Suicide accounts for at least 1 million deaths globally each year. This is likely a significant underestimate, because suicide is under-reported in many countries. In the US, over 42,000 people die from suicide annually. Despite increased focus on identification and treatment, the rate of suicide has increased steadily over the …

depression
suicidal
suicide
scid
  • 579 views
  • 17 Feb, 2022
  • 1 location
Pain, Reward, Attention and Neurocircuitry: Biomarkers of Suicidality

The ultimate aim of this study is to identify a biomarker of suicide risk in MDD by measuring the "hedonic spectrum" (pain and reward responsivity), attention and its associated brain structures using brain scans (fMRI and DTI), as well as the stability of markers over time.

depression
suicide
Accepts healthy volunteers
major depressive disorder, single episode
depressive episode
  • 446 views
  • 25 Feb, 2022
  • 1 location
MicroRNA Correlates of Childhood Maltreatment and Suicidality

This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA [MiRNA]) levels. miRNAs are a type of RNA (genetic material that is translated into …

Accepts healthy volunteers
depression
depressed mood
  • 32 views
  • 30 Apr, 2022
  • 2 locations
The Gut Microbiota of Bipolar and Depression

elucidating the complement of the gut microbiome community for individuals with Major Depressive disorder (MDD) and Bipolar disorder (BD) relative to controls, and test for relationships with symptoms.

depression
depressive disorder
Accepts healthy volunteers
bipolar disorder
psychiatric treatment
  • 283 views
  • 25 Feb, 2022
  • 1 location
Imaging mGluR5 and Synaptic Density in Psychiatric Disorders

This research study is designed to look at the involvement of the glutamate system and synaptic density in depression and bipolar disorder. Each participant will undergo a screening appointment to determine study eligibility. Thereafter, the study will take 2 or 3 visits depending on schedule availability and will consist of …

depression
depressive disorder
functional magnetic resonance imaging
depressed mood
psychiatric disorder
  • 91 views
  • 02 May, 2022
  • 1 location
A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women

Pregnant women who are taking lamotrigine will be evaluated monthly during pregnancy including a clinical evaluation and a blood draw for lamotrigine levels at each visit. Based on the Therapeutic Drug Monitoring protocol, participant's lamotrigine dosing will be adjusted as needed based on participant's blood levels compared to the reference …

lamictal
schizoaffective disorder
lamotrigine
depressive disorder
bipolar disorder
  • 24 views
  • 21 Feb, 2022
  • 1 location
  • 0 views
  • 27 Jan, 2021
  • 1 location