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Found 38 clinical trials
A Study of JNJ-55308942 in the Treatment of Bipolar Depression

The purpose of this study is to evaluate the efficacy of JNJ-55308942 compared to placebo on symptoms of depression in participants with bipolar disorder (BD) in a major depressive episode (MDE

depressive symptoms
depressed mood
body mass index
  • 11 Aug, 2022
  • 7 locations
Minocycline as Adjunctive Treatment for Treatment Resistant Depression (MINDEP2)

treatment approach. This study is a 12 week, double-blind, placebo-controlled trial of minocycline as add-on treatment for patients suffering from a major depressive episode who have failed to

a 12
  • 25 May, 2022
  • 1 location
bBeAMom: Effectiveness of a Cognitive-Behavioral Blended Intervention for Postpartum Depression (bBeAMom)

Be a mom program (a web-based cognitive-behavioral intervention) is being tested in another clinical trial as a preventive intervention for postpartum depression (NCT03024645). However, given its effectiveness in reducing depressive symptoms among women presenting early-onset postpartum depressive symptoms, Be a Mom can also have potential as a postpartum depression complement …

  • 23 Jul, 2022
  • 1 location
A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder.

A clinical trial to study the efficacy and safety of an investigational drug in people with major depressive episodes associated with with Bipolar I disorder (bipolar I depression) Participants in the study will either receive the drug being studied or a placebo. The study will be conducted in the United …

  • 28 Jul, 2022
  • 39 locations
COG-PSYCHO : Social Cognition and Psychotic Characteristics: Genetic and Phenomic Approach

Bipolar disorder (BD), schizophrenia and depression can feature cognitive impairment, especially in social cognition (SC). According to previous studies, some genes from the oxytocin and dopamine pathways may be involved SC performance. Our endophenotype approach aimed to demonstrate that SC deficits are more severe in schizophrenia and BD or depression …

  • 24 Jun, 2021
  • 1 location
Cerebral Neuroinflammation During Major Depressive Episode

the investigators make the following assumptions: 1) neuroinflammation in MDD can be measured by the [18 F ] DPA- 714 ; 2) it is accompanied by anatomical and functional changes in the frontal subcortical loops, strongly involved in MDD ; 3) neuroinflammation in patients might be a biomarker related to …

Accepts healthy volunteers
major depressive disorder
blood tests
  • 06 Nov, 2021
  • 4 locations
Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode (BUPRIS)

This study aims at investigating if adjunctive buprenorphine at low dose to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode, and at determining the

depressed mood
  • 27 Jul, 2022
  • 7 locations
Social Stress and Suicide (SUPHY)

Only vulnerable patients, when facing environmental stressors, attempt or commit suicide. Previous research demonstrated that suicide attempters usually misunderstand the social context and show impairments in decision making. Heart activity, endocrine and inflammatory response to stress were related with these features. For that, suicide attempters, in a context of social …

  • 22 Mar, 2022
  • 1 location
Predict MDE Outcomes After MST

This trial attempts to explore the treatment outcome of magnetic seizure therapy (MST) for major depressive episode. Half of the participants will receive MST, while the other half will receive

  • 09 Mar, 2022
  • 1 location
Comparing Uni- and Bi-lateral TBS in Major Depression

Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS) is a very promising new treatment for major depression that allows a 15-fold reduction in duration of daily sessions. However, no large scale naturalistic study has assessed the superiority of bilateral TBS …

  • 28 Jun, 2022
  • 1 location