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Found 10 clinical trials
Comparing Uni- and Bi-lateral TBS in Major Depression

Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS) is a very promising new treatment for major depression that allows a 15-fold reduction in duration of daily sessions. However, no large scale naturalistic study has assessed the superiority of bilateral TBS …

  • 6 views
  • 28 Jun, 2022
  • 1 location
Predict MDE Outcomes After MST

This trial attempts to explore the treatment outcome of magnetic seizure therapy (MST) for major depressive episode. Half of the participants will receive MST, while the other half will receive electroconvulsive therapy (ECT).

  • 0 views
  • 09 Mar, 2022
  • 1 location
Personalized Ultrasonic Brain Stimulation for Depression

This study will evaluate a new form of non-invasive brain stimulation for individuals with depression. Personalized low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation parameters during psychological and physiological monitoring. A well-tolerated stimulation protocol will then be selected for subsequent testing in a blinded …

  • 0 views
  • 07 Oct, 2022
  • 1 location
Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode (BUPRIS)

This study aims at investigating if adjunctive buprenorphine at low dose to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode, and at determining the most effective dose.

depressed mood
analgesic
depression
  • 0 views
  • 04 Oct, 2022
  • 7 locations
Ketamine as an Adjunctive Therapy for Major Depression (2)

Pragmatic, randomised, controlled, parallel-group, superiority trial of ketamine vs. midazolam as an adjunctive therapy for depression. The main purpose of the trial is to assess the mood-rating score difference between ketamine and midazolam from before the first infusion to 24 hours after the final infusion, supplemented by a 95% confidence …

depressed mood
ketamine
depression
depressive disorder
depressive episode
  • 54 views
  • 23 Sep, 2021
  • 1 location
Left vs. Right Non-Inferiority Trial

The aim of this study is to test the hypothesis that low-frequency rTMS (LFR) works as well as the established intermittent thetaburst rTMS (iTBS) treatment for treatment resistant depression (TRD).

antidepressants
depressed mood
hdrs
transcranial magnetic stimulation
  • 0 views
  • 18 Nov, 2021
  • 2 locations
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) (ELEKT-D)

The goal of the study is to conduct a comparative randomized trial of electroconvulsive therapy (ECT) vs. ketamine for patients with treatment resistant depression (TRD) in a real world setting with patient reported outcomes as primary and secondary outcome measures.

depression
antidepressants
depressive symptoms
depressive episode
major depressive disorder, single episode
  • 1992 views
  • 28 Oct, 2022
  • 5 locations
University of Iowa Interventional Psychiatry Service Patient Registry

The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' …

bipolar disorder
depressed
depression
antidepressants
depressive episode
  • 168 views
  • 06 May, 2022
  • 1 location
The Effects of Anger and Joy Expressions on Approach and Avoidance Behaviors in Healthy Volunteers

Social interactions are part of our daily lives. Communicating with others is a recurring choice which is based on emotional cues, such as facial expression. Our action must be adapted to the emotional state of our interlocutor, otherwise the investigators will have poor quality interactions An emotional stimulus would cause …

  • 75 views
  • 18 Sep, 2021
  • 1 location
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.

lithium
suicidal
bipolar disorder
depression
mania
  • 394 views
  • 12 Jul, 2021
  • 1 location