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Found 101 clinical trials
The Effects of Nicotinamide Riboside Supplementation on Brain NAD+/NADH Ratio and Bioenergetics

using phosphorus magnetic resonance spectroscopy (31P MRS) imaging. The secondary aims are to investigate the change in brain PCr/ATP and creatine kinase enzyme rate after NR use. In addition

Accepts healthy volunteers
  • 04 Mar, 2022
  • 1 location
Biomarkers of Conversion Risk and Treatment Response in Early-Stage Schizophrenia

proton magnetic resonance spectroscopy (1H MRS)-based biomarkers for monitoring treatment response in early stages of SZ. In support of the viability of this overall objective is a large body of data

Accepts healthy volunteers
  • 03 Mar, 2022
NAD+ Precursor Supplementation in Friedreich's Ataxia

The primary objective is to test the safety and tolerability of short-term therapy with a nicotinamide adenine dinucleotide (NAD+) precursor (MIB-626) in adults with Friedreich's Ataxia (FA) without overt heart failure and with a left ventricular ejection fraction ≥ 40%. A key secondary objective is to test the effects of …

molecular diagnosis
cardiac failure
ejection fraction
  • 09 May, 2022
  • 1 location
Probiotics, Immune Function, and the Brain in Alcohol Consumers

This pilot project is a brief, open-label clinical trial of probiotics as an intervention in heavy drinkers. Heavy drinkers who do not yet show significant signs of liver disease may stand to benefit from probiotics, but no clinical trials to date have addressed this population. This study will recruit heavy …

Accepts healthy volunteers
  • 16 Mar, 2022
  • 1 location
Cardiac Rehab Effects in HFpEF

This research in Veterans with heart failure with preserved ejection fraction (HFpEF) will provide new information on the mechanisms determining the patients' exercise intolerance and the efficacy of regular physical activity to improve this shortcoming by alleviating the patients' neurocirculatory abnormalities. Specifically, the investigators will focus on the role of …

Accepts healthy volunteers
  • 09 Jun, 2022
  • 1 location
Pathophysiology of Uric Acid Nephrolithiasis (IUAN)

This study has two aims: Aim 1: To determine the presence of accumulation of fat within cells and the functional consequences of this in the kidney by correlating kidney fat content with urine test results. Aim 2: The investigators will evaluate the effect of thiazolidinedione (pioglitazone) on excess fatty acid …

  • 24 Jan, 2022
  • 1 location
Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery

Bariatric surgery is an effective treatment for severe obesity but results in loss of muscle mass. The investigators will test the hypothesis that consumption of an Essential Amino Acid-based nutritional formulation will maintain muscle mass while stimulating fat loss after bariatric surgery.

bariatric surgery
protein supplement
sleeve gastrectomy
  • 21 Mar, 2022
  • 1 location
Brain Changes in Fear

The purpose of this study is to use brain imaging technology to investigate brain changes in people exposed to predictable versus unpredictable unpleasant stimuli. Unpleasant events that can be predicted evoke a response of fear, whereas unpredictable, unpleasant stimuli cause chronic anxiety not associated with a specific event. Information gained …

Accepts healthy volunteers
traumatic stress disorder
specific phobia
  • 19 Jun, 2022
  • 1 location
Non-Invasive Monitoring Of Metabolite Levels Using Novel And Adapted MR Spectroscopy Techniques (NIMM_MRS)

stable (suitable for routine clinical use). Magnetic resonance spectroscopy (MRS) is closely related to the widely used magnetic resonance imaging (MRI). Both methods are based on the same

Accepts healthy volunteers
  • 16 Jun, 2022
Optimising the Duration of Cooling in Mild Encephalopathy (COMET)

Phase II randomised control trial of whole body cooling in mild neonatal encephalopathy.

  • 14 Feb, 2022
  • 5 locations