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Found 10 clinical trials
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Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma(CLL/SLL), Lymphoplasmacytic Lymphoma(LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma(SMZL)

Background: The development of new technologies now allow scientists to investigate the molecular basis and clinical manifestations of monoclonal B cell lymphocytosis

lymphocytosis
cancer
lymphadenopathy
lymphoma
chronic lymphocytic leukemia
  • 88 views
  • 15 Apr, 2019
  • 1 location
featured
A Study of the Kinetics of Lymphoid Cells in Patients with Monoclonal B-Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL), Mantle Cell Lymphoma (MCL) and Healthy Volunteers

abnormal lymphocytes (a type of white blood cell). Monoclonal B-cell lymphocytosis (MBL) is a condition in which the individual has a larger than normal number of lymphocytes. Individuals with CLL, SLL, MBL

lymphocytosis
cancer
lymphoma
chronic lymphocytic leukemia
mantle cell lymphoma
  • 102 views
  • 15 Apr, 2019
  • 1 location
Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization

This phase Ib/II trial studies the side effects and best dose of ibrutinib and how well it works in treating patients with COVID-19 requiring hospitalization. Ibrutinib may help improve COVID-19 symptoms by lessening the inflammatory response in the lungs, while preserving overall immune function. This may reduce the need to …

absolute neutrophil count
human chorionic gonadotropin
anemia
growth factor
beta-human chorionic gonadotropin
  • 0 views
  • 25 Jan, 2021
  • 1 location
Study to Investigate the Use of Acalabrutinib in the Treatment of Patients With Chronic Lymphocytic Leukemia

Study Phase III Randomized Study to Investigate the Use of Acalabrutinib in the Treatment of Patients with Early Stage CLL With High Risk of Early Disease Progression. The study will consist of a screening phase, a treatment/observation phase until progression, and a follow-up phase for progression in patients who discontinue …

  • 0 views
  • 27 Jan, 2021
  • 24 locations
Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation

Background Blood stem cells in the bone marrow make all the cells to normally defend a body against disease. Allogeneic blood or marrow transplant is when these stem cells are transferred from one person to another. Researchers think this treatment can provide a new, healthy immune system to correct T-cell …

chest x-ray
hemophagocytic lymphohistiocytosis
immune globulin
anesthesia
bone marrow transplant
  • 138 views
  • 01 May, 2021
  • 2 locations
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM) and Splenic Marginal Zone Lymphoma (SMZL)

lymphocytosis (MBL), chronic lymphocytic leukemia(CLL)/small lymphocytic lymphoma (SLL), lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM), and splenic marginal zone lymphoma (SMZL). Applying

chemotherapy regimen
leukemia
lymphadenopathy
lymphoma
marginal zone lymphoma
  • 153 views
  • 19 Jun, 2021
  • 1 location
Immunogenicity and Safety of Commercially Available Vaccines Against SARS-CoV-2 (COVID-19) in Patients With Hematologic Malignancies

D1. Primary Objective: Determine the immunogenicity of FDA approved COVID-19 vaccination in patients with hematologic malignancies D2. Secondary Objectives: Assess the safety of FDA approved COVID-19 vaccination in patients with hematologic malignancies Analyze the kinetics of immunogenic response over time after receipt of the COVID-19 vaccination Compare the immunogenicity of …

  • 0 views
  • 18 Feb, 2021
  • 1 location
Family Study of Lymphoproliferative Disorders

Blood and lymph node cancers can begin in either the lymphatic tissues (as in the case of lymphoma) or in the bone marrow (as with leukemia and myeloma), and they all are involved with the uncontrolled growth of white blood cells. There are many subtypes of these cancers, e.g., chronic …

leukemia
lymphoproliferative disorder
white blood cells
lymphoma
hodgkin's disease
  • 77 views
  • 24 Jan, 2021
  • 1 location
Oxford Pre-cancerous Lymphoproliferative Disorders Study

OxPLoreD is an observational cohort study to identify clinical, genomic and immunological predictive markers of progression to malignant disease. Open to individuals diagnosed in the last 3 years with high count MBL, Binet Stage A CLL, Immunoglobulin G/A/M (IgG, IgA, IgM) MGUS, asymptomatic WM not requiring treatment and smouldering myeloma …

  • 3 views
  • 23 Jan, 2021
  • 1 location
CHIP/CCUS Natural History Protocol

Background Clonal Hematopoiesis of Indeterminate Potential (CHIP) is a change in a person s DNA that can increase a person s risk of developing blood cancers or cardiovascular disease. CHIP occurs mostly occurs in older people. Clonal cytopenia of undetermined significance (CCUS) occurs when one or more blood cell types …

  • 0 views
  • 24 May, 2021
  • 1 location