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Found 657 clinical trials
Safety and Preliminary Efficacy of JBH492 Monotherapy in Patients With Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin's Lymphoma (NHL)

The purpose of the First-In-Human study is to assess safety, tolerability, pharmacokinetics (PK), immunogenicity and preliminary efficacy of JBH492 as single agent.

chronic lymphocytic leukemia
lymphoid leukemia
hodgkin's disease
lymphoma
leukemia
  • 5 views
  • 14 Dec, 2021
  • 11 locations
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

relapsed/ refractory B-cell Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) in Part A and to further characterize the safety at the RP2D(s) in Part B.

chronic lymphocytic leukemia
marginal zone lymphoma
measurable disease
cell transplantation
b-cell lymphoma
  • 1 views
  • 09 Dec, 2021
  • 36 locations
A Study of JNJ-64264681 and JNJ-67856633 in Participants With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia

lymphoma (NHL) and chronic lymphocytic leukemia (CLL) (Part A - Dose Escalation); and the safety of the RP2Ds for this combination in different histologies/participant populations (Part B - Cohort

chronic lymphocytic leukemia
lymphoma
leukemia
  • 0 views
  • 09 Dec, 2021
  • 35 locations
Study of LOXO-305 Versus Investigator's Choice (IdelaR or BR) in Patients With CLL or SLL

This is a study for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL) who have previously received treatment with at least a BTK inhibitor. The main purpose is

chronic lymphocytic leukemia
rituximab
idelalisib
btk inhibitor
neutrophil count
  • 5 views
  • 17 Oct, 2021
  • 125 locations
Study to Assess the Efficacy and Safety of Ublituximab in Combination With Umbralisib and Venetoclax Compared to Ublituximab in Combination With Umbralisib in Subjects With CLL (ULTRA-V)

Lymphocytic Leukemia (CLL)

chronic lymphocytic leukemia
lymphoid leukemia
monoclonal antibodies
venetoclax
monoclonal protein
  • 23 views
  • 21 Jan, 2022
  • 50 locations
A Safety, Efficacy and Pharmacokinetic Study of BTCT4465A (Mosunetuzumab) as a Single Agent and Combined With Atezolizumab in Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

This is a Phase 1/2 dose-escalation study of BTCT4465A (Mosunetuzumab) administered as a single agent and in combination with atezolizumab in participants with relapsed or refractory B-cell NHL and CLL. The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.

chronic lymphocytic leukemia
lymphoid leukemia
hematologic malignancy
leukemia
lymphoma
  • 0 views
  • 25 Jan, 2022
  • 45 locations
A Study of JNJ-75276617 in Participants With Acute Leukemia

The purpose of this study is to determine the recommended Phase 2 dose(s) (RP2D[s]) of JNJ-75276617 in Part 1 (Dose Escalation) and to determine safety and tolerability at the RP2D(s) in Part 2 (Dose Expansion).

gilbert's syndrome
direct bilirubin
acute leukemia
hydroxyurea
serum bilirubin level
  • 4 views
  • 09 Jan, 2022
  • 27 locations
Study Evaluating Brexucabtagene Autoleucel (KTE-X19) in Pediatric and Adolescent Participants With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia or Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (ZUMA-4)

-precursor acute lymphoblastic leukemia (ALL) or relapsed or refractory (r/r) B-cell non-Hodgkin lymphoma (NHL).

fludarabine
lymphoid leukemia
pleural effusion
cyclophosphamide
b-cell lymphoma
  • 0 views
  • 26 Jan, 2022
  • 23 locations
Study of Efficacy and Safety of Tisagenlecleucel in HR B-ALL EOC MRD Positive Patients

This is a single arm, open-label, multi-center, phase II study to determine the efficacy and safety of tisagenlecleucel in de novo HR pediatric and young adult B-ALL patients who received first-line treatment and are EOC MRD positive. The study will have the following sequential phases: screening, pre-treatment, treatment & follow-up, …

gilbert's syndrome
methotrexate
flow cytometry
renal function
oxygen saturation
  • 42 views
  • 20 Jan, 2022
  • 60 locations
A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

The purpose of this study is to compare the efficacy and safety of fixed duration pirtobruitinib (LOXO-305) with VR (Arm A) compared to VR alone (Arm B) in patients with CLL/SLL who have been previously treated with at least one prior line of therapy. Participation could last up to five …

chronic lymphocytic leukemia
rituximab
venetoclax
neutrophil count
lymphoma
  • 0 views
  • 25 Nov, 2021
  • 27 locations