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Found 365 clinical trials
Featured trial
A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia

This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of the study will optimize the dose of study drug (ruxolitinib) in combination with the chemotherapy regimen. Part 2 will evaluate the efficacy of combination …

combination chemotherapy
thioguanine
prednisone
cyclophosphamide
pegaspargase
  • 5 views
  • 28 Oct, 2022
  • 94 locations
Featured trial
AALL0932: Treatment of Patients with Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic Leukemia (ALL)

AALL0932: Treatment of Patients with Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic Leukemia (ALL)

  • 112 views
  • 08 Nov, 2020
  • 1 location
Featured trial
AALL0434: Combination Chemotherapy in Treating Young Patients with Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia

AALL0434: Combination Chemotherapy in Treating Young Patients with Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia

  • 171 views
  • 08 Nov, 2020
  • 1 location
Featured trial
AALL08B1: Risk-Based Classification System of Patients with Newly Diagnosed Acute Lymphoblastic Leukemia

AALL08B1: Risk-Based Classification System of Patients with Newly Diagnosed Acute Lymphoblastic Leukemia

  • 112 views
  • 08 Nov, 2020
  • 1 location
Featured trial
AALL1131, A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789) in the Very High Risk Stratum.

AALL1131, A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789) in the Very High Risk Stratum.

  • 233 views
  • 08 Nov, 2020
  • 1 location
Featured trial
AALL0631: A Phase III Study of Risk Directed Therapy for Infants with Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition (CEP-701, Lestaurtinib; IND #76431; NSC# 617807)

AALL0631: A Phase III Study of Risk Directed Therapy for Infants with Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition (CEP-701, Lestaurtinib; IND #76431; NSC# 617807)

  • 366 views
  • 08 Nov, 2020
  • 1 location
CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia) (CiproPAL)

CiproPAL is a randomised trial comparing daily ciprofloxacin with local standard care during the induction phase of paediatric ALL treatment, and aims: To assess the efficacy of ciprofloxacin prophylaxis in the reduction of infection during the induction phase of treatment for paediatric Acute Lymphoblastic Leukaemia within the ALLTogether-1 Trial. To …

  • 0 views
  • 04 Oct, 2022
  • 1 location
A Phase 1/2 Open-label Study to Investigate the Safety, Efficacy, and Pharmacokinetics of Administration of Subcutaneous Blinatumomab for the Treatment of Adults With Relapsed or Refractory B Cell Precursor Acute Lymphoblastic Leukemia (R/R B-ALL)

The study aims to evaluate the safety, efficacy, and tolerability of subcutaneous (SC) blinatumomab for treatment of Acute Lymphoblastic Leukemia (ALL) and to determine the maximum tolerated dose (MTD), and recommended phase 2 dose (RP2D) of SC administered blinatumomab.

  • 0 views
  • 14 Oct, 2022
  • 22 locations
Evaluation of Therapeutic Video Games for Pre-school Children With Acute Lymphoblastic Leukemia

The purpose of this study is to evaluate the effectiveness of therapeutic video game.

  • 0 views
  • 10 Sep, 2021
  • 1 location
CD19 CAR-T Consolidation Therapy for Acute Lymphoblastic Leukemia

This is a single arm, open-label, single-center, phase I/II study to determine the safety and efficacy of CD19 CAR-T( ssCART-19) combined with feeding T cells (FTCs) as consolidation therapy in patients diagnosed with de novo Philadelphia chromosome positive CD19+ B-ALL. The study will contain the following sequential phases: screening, lymphocyte …

  • 0 views
  • 24 May, 2022
  • 1 location