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Found 203 clinical trials
FAPI PET for Lung Fibrosis (FAPI ILD)

This is a prospective exploratory biodistribution study in patients with interstitial lung disease (ILD). The purpose of this research study is to determine where and to which degree the FAPI tracer (68Ga-FAPI-46) accumulates in normal and fibrotic lung tissues of patients with interstitial lung disease. The study will include patients …

  • 16 May, 2022
  • 1 location
Infants With Severe Acute Respiratory Distress Syndrome: The Prone Trial

The main objective is to determine the short-term effect of prone positioning in infants with infection-associated severe acute respiratory distress syndrome. The investigators compare oxygenation parameters and measurements from electrical impedance tomography (EIT) and lung ultrasonography (LUS) in mechanically ventilated infants in prone position versus supine position after surfactant administration.

  • 21 Apr, 2022
  • 1 location
Duodenal Feeds in Very Low Birth Weight Infants

risk for gastroesophageal reflux and aspiration which may exacerbate lung injury. Transpyloric feeds, specifically duodenal feeds, may be used to bypass the stomach and directly feed the duodenum

  • 28 Sep, 2021
  • 1 location
Ultraprotective Ventilation Without Extracorporeal Circulation During COVID 19 Pneumonia

appears to exceed standard duration of mechanical ventilation in non-COVID-19 ARDS patients, suggesting that COVID-19 patients may be particularly at risk for ventilator-induced lung injury. Treatment of

  • 25 Feb, 2021
  • 11 locations
Paediatric Ards Neuromuscular Blockade Study (PAN)

Paediatric acute respiratory distress syndrome (ARDS) is a manifestation of severe, life-threatening lung injury. Care for paediatric patient is mainly supportive and based on what works in

mechanical ventilation
chest radiograph
neuromuscular blocking agents
ventilator-induced lung injury
positive end expiratory pressure
  • 21 Feb, 2022
  • 1 location
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer

Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them …

  • 29 Jan, 2021
  • 2 locations
Optimal PEEP Titration Combining Transpulmonary Pressure Measurement and Electric Impedance Tomography

Diagnosis and treatment of the hypoxic respiratory failure induced by severe atelectasis with the background of acute lung injury is challenging for the intensive care physicians. Mechanical

mechanical ventilation
respiratory failure
  • 25 Mar, 2022
  • 1 location
Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma

. DAMPs then bind leukocytes and trigger NETosis (Neutrophil Extracellular Traps), the release of nuclear material coated with proteolytic enzymes, which ultimately promotes remote lung injury and acute

mechanical ventilation
respiratory failure
injuries pelvic
  • 11 Sep, 2021
  • 1 location
Image-Guided Functional Lung Avoidance Thoracic Radiotherapy for Lung Cancer: A Single-Blind Randomized Trial

recognized to cause moderate to severe lung injury in a substantial portion of patients. Conventional standard curative TRT planning techniques minimize the radiation dose to the anatomical lungs, without

  • 23 Feb, 2022
Autoantibody Reduction for Acute Exacerbations of Idiopathic Pulmonary Fibrosis (STRIVE-IPF)

ameliorate autoantibody-mediated pulmonary injury. Anecdotal pilot studies indicate these treatments have significant benefit for a disease syndrome that has, until now, been almost invariably inexorable

  • 25 Mar, 2022
  • 6 locations