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Found 206 clinical trials
Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated Outcomes

Patent ductus arteriosus (PDA), very common in preterm infants, is the delayed closure of a fetal blood vessel that limits blood flow through the lungs. PDA is associated with mortality and harmful long term outcomes including chronic lung disease and neurodevelopmental delay. Although, treatments to close PDA likely benefit some …

patent ductus arteriosus
chronic lung disease
h-fabp
pulmonary disease
  • 0 views
  • 08 Feb, 2022
  • 4 locations
Targeted vs Standard Fortification of Breast Milk

BACKGROUND Human milk (HM) is recommended for all very low birth infants (VLBW)). Breast-milk is highly variable in nutrient content, failing to meet the nutritional demands of VLBW. Fortification of HM is recommended to prevent extra-uterine growth retardation and associated poor neurodevelopmental outcome. However, standard fortification with fixed dose multicomponent …

very low birth weight
sepsis
necrotizing enterocolitis
bronchopulmonary dysplasia
prematurity
  • 0 views
  • 26 Mar, 2022
  • 1 location
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia

The purpose of this study is to use forced oscillometry technique (FOT) to measure pulmonary mechanics and function in premature infants with bronchopulmonary dysplasia (BPD)

bronchopulmonary dysplasia
prematurity
premature birth
  • 24 views
  • 27 Feb, 2022
  • 1 location
CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial

The purpose of this study is to determine if in preterm infants < 34 weeks' gestation at birth receiving respiratory support with continuous positive airway pressure (CPAP) or nasal cannula (NC), CPAP compared with NC will decrease the number of episodes with oxygen saturations less than 85% of 10 seconds …

  • 0 views
  • 01 Sep, 2021
  • 1 location
Optimal Dose of Surfactant for Preterm Infants With Respiratory Distress Syndrome

In preterm infants with neonatal respiratory distress syndrome (RDS), exogenous pulmonary surfactant(PS) replacement therapy is one of the most important therapeutic breakthrough to reduce neonatal incidences of bronchopulmonary dysplasia(BPD) and/or death. But not all preterm infants with RDS can be beneficial. Otherwise, the international neonatal acute RDS (NARDS) collaborative group …

  • 0 views
  • 26 Aug, 2021
  • 1 location
Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants

Oxygen treatment is common in management of preterm babies requiring intensive care. Delivery of too much or too little oxygen increase the risk of damage to eyes and lungs, and contributes to death and disability. Oxygen control in preterm infants requires frequent adjustments in the amount of oxygen delivered to …

  • 0 views
  • 09 Sep, 2021
  • 3 locations
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease

This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand lung structure and function and evaluate response to therapy delivered as a part of clinical care.

respiratory infection
trypsin
malnutrition
lung disease
Accepts healthy volunteers
  • 547 views
  • 27 Feb, 2022
  • 1 location
High-flow Nasal Oxygenation and Non-invasive Ventilation Strategies for the Treatment of Covid-19 Pneumonia

HFNO and NIV strategies are the most commonly used strategies for the treatment of hypoxia in patients with a diagnosis of COVID-19 who are still followed in the intensive care unit, but there is no study comparing the two yet. In our prospective study, we aimed to compare these two …

  • 0 views
  • 05 May, 2022
  • 1 location
Measurement of Airway Opening Pressure (AOP) in Patients With Acute Respiratory Distress Syndrom and With or Without Covid 19.

Mechanical ventilation in ARDS requires protective ventilation and PEEP. Airway closer has to be overcome to reduce lung heterogeneity, AOP is measured globally with a ventilator PV curve without PEEP. EIT derived PV curve is another method that could determine heterogeneity of AOP between both lung. This study aims to …

acute respiratory distress
assisted ventilation
electrical impedance tomography
positive end expiratory pressure
mechanical ventilation
  • 0 views
  • 19 Jun, 2021
  • 1 location
Galectin and Respiratory Weaning (Gal-3)

Galectin-3 is a biomarker for fibrotic activity. In the course of invasive ventilation, fibrotic changes in the lungs may occur. The study aims to investigate whether the level of galectin-3 levels correlates with clinical weaning parameters.

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
  • 1 location