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Found 206 clinical trials
Prediction of Adverse Outcome Using Fetal MRI in Pregnancies at Risk of Preterm Birth

1.4% of babies have a very premature birth (PTB) (less than 32 weeks of pregnancy). This can result in severe life-long complications including cerebral palsy, learning and behavioural difficulties and breathing problems. This has significant cost implications for the NHS, education services and immeasurable human costs for the child and …

Accepts healthy volunteers
  • 22 Apr, 2022
Assessment of Regional Lung Ventilation Distribution During Supraglottic and Subglottic Jet Ventilation by EIT.

Objective: To estimate regional lung volume changes by electrical impedance tomography (EIT) during supra- and subglottic jet ventilation via the jet laryngoscope and LaserJet catheter for performing laryngotracheal surgery. Design: A monocentric, prospective, randomized study. Patients: Patients who require elective micro laryngo-tracheal surgery under jet ventilation. Interventions: Patients undergoing elective …

  • 01 Mar, 2022
  • 1 location
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).

Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating. Opening their lungs can be difficult, and once open the under-developed lungs of premature babies will often collapse again between each breath. To prevent this nearly all premature babies …

chronic lung disease
mechanical ventilation
positive end expiratory pressure
assisted ventilation
  • 14 Nov, 2021
  • 19 locations
Efficacy and Safety Study of BDB-001 in Severe COVID-19 With ALI/ARDS

This multi-center, open, randomized study will evaluate the efficacy and safety of BDB-001 injection in severe COVID-19 with severe pneumonia, or acute lung injury/acute respiratory distress

acute respiratory distress
respiratory distress
  • 24 Mar, 2022
  • 10 locations
Pulmonary Function Using Non-invasive Forced Oscillometry (PUFFOR)

The purpose of this observational study is to measure pulmonary function in term and preterm infants with and without pulmonary disease including respiratory distress syndrome, bronchopulmonary dysplasia, transient tachypnea of the newborn, meconium aspiration syndrome, and response to treatments given to newborn infants with lung diseases using a non-invasive airway …

transient tachypnea of newborn
transient tachypnea of the newborn
continuous positive airway pressure
pulmonary disease
bronchopulmonary dysplasia
  • 05 Apr, 2022
  • 1 location
Early PReserved SPONtaneous Breathing Activity in Mechanically Ventilated Patients With ARDS (PReSPON)

exists over the net effects of preserved early spontaneous breathing activity with regard to ventilator-associated lung injury (VALI). In fact, by taking advantage of the potential improvement in

  • 15 Feb, 2021
  • 1 location
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19)

This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a …

acute respiratory distress
mechanical ventilation
assisted breathing
  • 23 Jul, 2021
  • 23 locations
SEvoflurane for Sedation in ARds (SESAR)

This study evaluates whether a sedation with inhaled sevoflurane will decrease mortality and increase time off the ventilator at 28 days in patients with acute respiratory distress syndrome (ARDS). Half of the patients will receive inhaled sedation with sevoflurane and the other half will receive intravenous sedation with propofol.

respiratory failure
acute respiratory distress
fluid overload
respiratory symptom
  • 24 Mar, 2022
  • 27 locations
GLP-1 and Hyperoxia for Organ Protection in Heart Surgery (GLORIOUS)

Patients undergoing open heart surgery are at risk of suffering damage to the heart, brain and kidneys. This study is designed as a 2-by-2 randomized clinical trial with the purpose of investigating the organ protective effects of the glucagon-like-peptide-1 (GLP-1) agonist Exenatide versus placebo and restrictive versus liberal oxygenation during …

ischemic heart disease
heart surgery
percutaneous coronary intervention
  • 27 Jan, 2022
  • 1 location
Tuberculosis (TB) Aftermath

TB Aftermath will compare effectiveness, cost-effectiveness and feasibility of two ACF strategies that are presently being considered by the RNTCP for detecting recurrent TB and provide evidence needed to implement and scale the preferred intervention. The proposed study will address this gap, through the following specific aims: Primary Aim 1: …

Accepts healthy volunteers
  • 12 May, 2022
  • 1 location