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Found 1909 clinical trials
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Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

This study will evaluate the safety and effectiveness of treating patients with severe aplastic anemia (SAA) or myelopdysplastic syndrome (MDS) with both peripheral blood stem cells from a family member and umbilical cord blood stem cells from an unrelated donor. Patients with SAA or MDS for whom other treatments have …

aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
anemia
anemia studies
  • 48 views
  • 22 Dec, 2020
  • 1 location
featured
A Randomized Trial of Sirolimus (Rapamune) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Background: People with severe aplastic anemia (SAA) do not make enough red and white blood cells, and/or platelets. Their body's immune system stops the bone marrow from making these cells. The treatment cyclosporine leads to better blood counts. But when this treatment is stopped, the disease may return in 1 …

aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
anemia
anemia studies
  • 61 views
  • 22 Dec, 2020
  • 1 location
featured
Haplo-identical Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using Peripheral Blood Stem Cells and Post-Transplant Cyclophosphamide for GVHD Prophylaxis

Background: Severe aplastic anemia (SAA) and myelodysplastic syndrome (MD) cause serious blood problems. Stem cell transplants using bone marrow or blood plus chemotherapy can help. Researchers want to see if using peripheral blood stem cells (PBSCs) rather than bone marrow cells works too. PBSCs are easier to collect and have …

aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
anemia
anemia studies
  • 57 views
  • 22 Dec, 2020
  • 1 location
featured
An Open-Label, Dose-Escalation, Safety Tolerability Study of INCAGN01876 in Subjects With Advanced or Metastatic Solid Tumors

An Open-Label, Dose-Escalation, Safety Tolerability Study of INCAGN01876 in Subjects With Advanced or Metastatic Solid Tumors

solid tumor
advanced solid tumor
solid tumors
  • 80 views
  • 08 Dec, 2020
  • 7 locations
featured
Prevention of venous thromboembolism (VTE) in cancer patients at high risk for VTE and who are undergoing chemotherapy

Prevention of venous thromboembolism (VTE) in cancer patients at high risk for VTE and who are undergoing chemotherapy

  • 114 views
  • 08 Nov, 2020
  • 1 location
featured
Lung Neuroendocrine Tumors

Lung Neuroendocrine Tumors

  • 26 views
  • 08 Nov, 2020
  • 1 location
Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

This study will compare the effectiveness of osimertinib alone with the combination of osimertinib and chemotherapy (carboplatin and pemetrexed) in people with metastatic lung cancer that has a

EGFR
liver metastasis
cancer
carboplatin
lung metastases
  • 0 views
  • 14 Apr, 2021
  • 11 locations
A Trial of TAK-788 (AP32788) in Non-small Cell Lung Cancer (NSCLC)

The purpose of this phase 1/2 study is to evaluate the safety, recommended phase 2 dose (RP2D), dose limiting toxicities (DLTs), maximum tolerated dose (MTD), pharmacokinetics of oral TAK-788 and its active metabolites, anti-tumor activity of TAK-788 in participants with NSCLC with epidermal growth factor receptor (EGFR) or human epidermal …

EGFR
stage iv non-small cell lung cancer
egfr t790m
afatinib
HER2
  • 0 views
  • 27 Jan, 2021
  • 98 locations
Sublobar Resection Versus Lobectomy for cT1N0M0 Non-small-cell Lung Cancer

inferior to lobectomy for cT1N0M0 non-small-cell lung cancer or not.

lung carcinoma
  • 0 views
  • 22 Jan, 2021
  • 1 location
A Study of Durvalumab as Consolidation Therapy in Non-Small Cell Lung Cancer Patients

with locally advanced, unresectable, non-small cell lung cancer (Stage III), who have not progressed following definitive, platinum-based, chemoradiation therapy.

chemoradiotherapy
lung carcinoma
durvalumab
  • 284 views
  • 18 Apr, 2021
  • 145 locations