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Found 1910 clinical trials
Patient-Derived Xenografts to Reduce Cancer Health Disparities

This trial establishes patient-derived cancer xenografts in addressing cancer health and treatment disparities that disproportionately affect racial/ethnic minorities. Understanding the genetic and response differences among racial/ethnic minorities may help researchers enhance the precision of therapeutic treatments.

cancer
lung carcinoma
bladder cancer
primary cancer
bladder tumor
  • 0 views
  • 24 Jan, 2021
  • 2 locations
Gender Difference in sidE eFfects of ImmuNotherapy: a Possible Clue to Optimize cancEr tReatment

The study aim is to investigate the differences between sex and gender in the immune-related adverse events (irAEs) development associated with immune checkpoint inhibitors (ICI) treatment. The study will be a multicenter prospective observational study focusing on biological differences between females and males, possibly affecting discrepant irAEs incidence.

cancer
immunologic adjuvant
cancer treatment
breast cancer
renal function test
  • 0 views
  • 25 Jan, 2021
  • 1 location
Improving Cancer Symptom Management

Patient-reported outcome measures (PROMs) is an umbrella term that refers to any report on a health status measure that is reported directly by the patient, without the influence of clinicians or anyone else. PROMs have been shown to more closely reflect a patient's daily health status when compared to physician-reported …

  • 0 views
  • 26 Jan, 2021
  • 4 locations
Collection of Blood Bone Marrow Tumor or Tissue Samples From Patients With Cancer to Study Drug Resistance

This study will examine blood, bone marrow, tumor and tissue samples from patients with cancer to study tumor resistance to chemotherapy (drug treatment). Many patients with cancer improve initially with chemotherapy, but then have a disease relapse, after which their tumor no longer responds to treatment. Other patients tumors are …

cancer
treatment regimen
recurrent disease
x-rays
  • 44 views
  • 14 Apr, 2021
  • 1 location
Immune Related-adverse Events in Patients Receiving Immune Checkpoint Inhibitors

The recent introduction of anti-PD-1 (nivolumab and pembrolizumab) and anti- PD-L1 (atezolizumab, durvalumab, avelumab) immune checkpoint inhibitors revolutionized oncological guidelines. Durable responses and prolongation of survival with these agents come at the price of the development of immune related adverse events (irAEs). Innovative tools are required in order to manage …

histological diagnosis
avelumab
cancer
lymphoma
lung cancer
  • 3 views
  • 23 Jan, 2021
  • 2 locations
Glucocorticoids Immunotherapy and Radiosurgery for Brain Metastases

Background. Brain metastases are the most common intracranial tumor and occur in 20-40% of all oncological patients. The most common primary cancer in brain metastases is lung cancer, followed

targeted therapy
whole-brain radiotherapy
cancer
metastasis
breast cancer
  • 0 views
  • 24 Jan, 2021
Association Between Proton Pump Inhibitors and Hematologic Toxicity of Pemetrexed

Pemetrexed is a multi-folate inhibitor approved in the treatment of non-small cell lung cancer (NSCLC) and pleural mesothelioma. Its toxicity profile is mainly hematologic (anemia, neutropenia

  • 26 views
  • 23 Jan, 2021
  • 1 location
Early Rebiopsy to Identify Biomarkers of Tumor Cell Survival Following EGFR ALK ROS1 or BRAF TKI Therapy

A comparison of baseline tumor characteristics in oncogene-driven cancers to tumor characteristics after early response to Tyrosine Kinase Inhibitor (TKI) targeted treatment will allow identification of early adaptive mechanisms of cell survival. This will facilitate targeting and termination of these survival/ resistance pathways before they develop with rational combinations of …

measurable disease
tyrosine
lung adenocarcinoma
osimertinib
gefitinib
  • 28 views
  • 28 Jan, 2021
  • 1 location
Characterizing Chemo-Radiotherapy Treatment-Related Cardiac Changes in Non-metastatic Non-recurrent Lung and Esophageal Cancer Patients

This trial studies cardiac changes after radiation or chemo-radiation for the treatment of lung or esophageal cancer that has not spread to other places in the body (non-metastatic) or has not come back (non-recurrent). Continuous cardiac monitoring with an implanted device may help to identify cardiac changes that would remain …

  • 0 views
  • 27 Jan, 2021
  • 1 location
4D-MRI for Precision Medicine

The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth …

  • 0 views
  • 28 Jan, 2021
  • 1 location