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Found 1867 clinical trials
Biospecimen Procurement for Genitourinary Malignancies and Experimental Transplantation and Immunology Branch Immunotherapy Protocols

Background Cancer has a major impact in the United States and across the world. In 2015, over 1.5 million new cases of cancer were diagnosed in the U.S. Researchers want to study samples from people with cancer or a pre-malignant condition. They hope to develop more effective treatments. Objective To …

ct scan
cancer
apheresis
platelet count
bone marrow procedure
  • 10 views
  • 29 Jan, 2021
  • 1 location
Breathomics as Predictive Biomarker for Checkpoint Inhibitor Response

Immunotherapy with agents stimulating the immune system to act against cancer are now a new standard of care in various cancers as lung cancer and melanoma, but also bladder cancer, kidney

lung cancer
cancer
cancer chemotherapy
ipilimumab
solid tumour
  • 1 views
  • 24 Jan, 2021
Paclitaxel Therapeutic Drug Monitoring in Cancer Patients

The goals of this prospective, observational cohort study are to determine the feasibility of implementing paclitaxel therapeutic drug monitoring for cancer patients and explore the relationship between paclitaxel drug exposure and the development of neuropathic symptoms. This trial studies if paclitaxel can be consistently measured in the blood of patients …

neuropathy
cyclophosphamide
gemcitabine
lung cancer
breast cancer
  • 0 views
  • 28 Jan, 2021
  • 1 location
Immunohistochemical Evaluation of Protein P16 Expression in Ovarian Germ Cell Tumors.

lung cancer [11].One member which is recently approved by US FDA is palbociclib for use in postmenopausal women with breast cancer [12].Thus, it is necessary to do further researches on its expression

germ cell tumor
breast cancer
carcinoma
  • 2 views
  • 28 Jan, 2021
  • 1 location
Evaluating Mutations in MET and TP53 Among Patients Diagnosed With Squamous Cell Carcinoma

This study focuses on advanced lung and head and neck SCC tumours, with adjacent normal lung tissues. Biopsies will be performed in National University Health System, Singapore (NUHS) as part of participants' standard care. Patient blood was also required for extraction of cell free DNA (cfDNA) and genomic DNA (gDNA). …

TP53
metastatic squamous cell carcinoma
cancer
squamous cell carcinoma
  • 2 views
  • 22 Jan, 2021
  • 1 location
Multimodal Monitoring of Radiotherapy Response in Squamous Cell Cancer

The study's aim is to define imaging and molecular bio-markers for prediction of radiotherapy response of squamous cell carcinomas, in an early treatment phase.

cancer
cervical disease
medical therapy
cavities
squamous cell carcinoma
  • 29 views
  • 25 Jan, 2021
  • 3 locations
Appropriate Dosing to Optimise Personalised Cancer Treatments

This is a pilot study to assess feasibility of dried blood spot (DBS) samples for pharmacokinetic measurements of targeted anti-cancer drugs in oncology patients such as patients with BRAF-mutant melanoma receiving targeted treatment with BRAF and MEK inhibitors.

cancer
KIT
ovarian epithelial carcinoma
carcinoma
lung carcinoma
  • 0 views
  • 25 Jan, 2021
  • 1 location
International Ovarian & Testicular Stromal Tumor Registry

been found to be associated with a lung cancer of early childhood called pleuropulmonary blastoma (PPB). The cause of these ovarian tumors is unknown. DICER1 mutations are seen in the majority of

  • 0 views
  • 22 Jan, 2021
  • 1 location
The Efficacy of Immunodetection Point Inhibitors for Advanced Esophageal Cancer

solid tumors including melanoma, non-small cell lung cancer and kidney cancer. These immunocheckpoint inhibitors have also been tried for esophageal cancer, with initial success in immunotherapy for

  • 0 views
  • 23 Jan, 2021
  • 1 location
Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer Moonshot Study

This trial studies the genetic analysis of blood and tissue samples from patients with cancer that has spread to other anatomic sites (advanced) or is no longer responding to treatment. Studying these samples in the laboratory may help doctors to learn how genes affect cancer and how they affect a …

cancer
recurrent disease
targeted therapy
investigational drug
biospecimen collection
  • 38 views
  • 16 Feb, 2021
  • 111 locations