Found 104 clinical trials
Albuterol in Patients With Lymphangioleiomyomatosis
to block the flow of air. It is a progressive disease, and in severe cases may require a lung transplant. One possible treatment to improve breathing in people with LAM is inhaled albuterol. Albuterol
- 94 views
- 22 Dec, 2020
- 1 location
Safety and Efficacy of Itacitinib in Participants With Bronchiolitis Obliterans Syndrome Following Lung Transplantation
The purpose of this study is to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of itacitinib in participants with post-lung transplant bronchiolitis obliterans syndrome (BOS
- 21 views
- 19 Dec, 2022
- 7 locations
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Sotatercept When Added to Maximum Tolerated Background Therapy in Participants With Pulmonary Arterial Hypertension (PAH) World Health Organization (WHO) Functional Class (FC) III or FC IV at High Risk Mortality (ZENITH)
) therapy) versus placebo (plus maximum tolerated background PAH therapy) on time to first event of all cause death, lung transplantation, or PAH worsening-related hospitalization of ≥24 hours, in
- 0 views
- 22 Oct, 2022
- 27 locations
An Open-label Extension Study Evaluating the Long-term Safety and Efficacy of Oral Inhalation of GB002 for the Treatment of WHO Group 1 Pulmonary Arterial Hypertension (PAH)
This open-label extension study will evaluate the long-term effects of GB002 (seralutinib) in subjects who previously participated in a GB002 PAH study.
- 0 views
- 22 Oct, 2022
- 28 locations
Hyperpolarized MRI of Lung Transplants
Chronic complications such as chronic lung allograft dysfunction (CLAD) remain the leading cause of death and the primary limitation to long-term survival for lung transplant recipients. CT is
- 0 views
- 10 Jul, 2022
- 1 location
Viral Load Guided Immunosuppression After Lung Transplantation (VIGILung)
The VIGILung study is an open-label, randomized, multicenter trial in lung transplant recipients to investigate the safety and efficacy of personalized immunosuppression guided by DNA monitoring
- 0 views
- 10 Jul, 2022
- 2 locations
Hp129 Xenon Imaging and BOS in Lung Transplantation
transplanted recipients who survive 5 years after transplant. Although lung transplantation has evolved into an effective therapeutic option for a large number of pediatric patients with end-stage pulmonary
- 10 views
- 05 Mar, 2022
- 1 location
Improving Lung Transplant Outcomes With Coping Skills and Physical Activity (INSPIRE-III)
This study evaluates the effectiveness of a coping skills and exercise (CSTEX) intervention among post lung transplant patients aimed to reduce distress and improve functional capacity. Half of
- 0 views
- 26 Apr, 2022
- 1 location
Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant
-1 in preventing bronchiolitis obliterans syndrome (BOS) progression in participants with a bilateral lung transplant To evaluate the effectiveness of ARINA-1 on improving quality of life
- 0 views
- 06 Apr, 2023
- 4 locations
Adipose Derived Mesenchymal Cell Treatment in Lungtransplantation
To investigate safety of treatment with allogeneic adipose tissue-derived mesenchymal stromal cells (ASCs) in patients undergoing lung transplantation, to evaluate whether the treatment can
- 0 views
- 24 Jul, 2021
- 1 location