Found 60 clinical trials
NSABP B-51: A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
NSABP B-51: A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before
- 114 views
- 08 Nov, 2020
- 1 location
Intensity Modulated Radiotherapy (IMRT) vs. 3D-conformal Accelerated Partial Breast Irradiation (APBI) for Early Stage Breast Cancer After Lumpectomy
In the setting of radiotherapy as part of breast-conservation therapy for patients with early stage breast cancer, the novel planning and delivery method of intensity modulated radiotherapy is an effective and safe alternative to the commonly-used standard 3D-conformal external beam radiotherapy, spares more normal breast and lung tissue, and may …
- 7 views
- 08 Nov, 2020
- 1 location
Radiofrequency Ablation After Breast Lumpectomy (ABLATE)
The main purpose of the study is to study the effectiveness of using a technique called RadioFrequency Ablation (RFA) after the breast tumor has been surgically removed. Ablation means cells are destroyed. The RFA device creates heat that destroys any cells in the area around where the tumor is removed, …
- 4 views
- 08 Nov, 2020
- 1 location
An Investigator Initiated Study of Intra-Operative Radiation Therapy (IORT) Using the Xoft Axxent eBx System
Single arm, prospective, multi-center, non-randomized study of subjects treated with single fraction, intra-operative radiation therapy at the time of lumpectomy for early stage breast cancer.To
- 0 views
- 12 Sep, 2021
- 1 location
Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer
Women with BRCA germline mutations face a very high risk of developing breast cancer during their lives. It was shown that for carrier patients, breast conservation, comprising of lumpectomy
- 6 views
- 23 Jan, 2022
- 1 location
Single Step Lesion Annotation and Localization of Suspicious Breast Lesions
the implanted reflector. After excision of the breast lesion, the handheld reader can be used to immediately confirm removal of the reflector, present in the lumpectomy specimen, and subsequent
- 0 views
- 28 Apr, 2022
- 1 location
Selective Omission of Axillary Surgery in Triple-negative and HER2-positive Breast Cancer After NACT
patients who achieve pCR in breast after NACT determined by lumpectomy. The trial is designed as a prospective, single-center, single-arm study with a limited number of patients (N=136). Patients
- 0 views
- 05 May, 2022
- 1 location
Repeat Sentinel Lymph Node Biopsy in Ipsilateral Breast Tumor Recurrence
According to the standard treatment guidelines established until recently, in the case of ipsilateral breast tumor recurrence without systemic metastasis, salvage mastectomy or lumpectomy can be
- 0 views
- 07 Aug, 2021
- 1 location
A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy.
- 0 views
- 16 Sep, 2022
- 412 locations
Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery
This phase IV trial studies the side effects of intraoperative radiation therapy and how well it works in treating patients with breast cancer undergoing breast-conserving surgery. Delivering radiation one time to the area where the tumor was removed while the patient is still in the operating room may kill any …
- 101 views
- 04 Oct, 2022
- 27 locations