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Found 54 clinical trials
Featured trial
Respiratory Syncytial Virus (RSV)

This randomized, double-blinded, placebo-controlled Phase 3 study is designed to assess the safety, immunogenicity, and efficacy of RSVpreF in the prevention of moderate to severe LRTI-RSV in

  • 0 views
  • 18 Apr, 2022
  • 1 location
A PHASE 3 STUDY TO EVALUATE THE EFFICACY, IMMUNOGENICITY, AND SAFETY OF RESPIRATORY SYNCYTIAL VIRUS (RSV) PREFUSION F SUBUNIT VACCINE IN ADULTS (RENOIR)

This randomized, double-blinded, placebo-controlled Phase 3 study is designed to assess the safety, immunogenicity, and efficacy of RSVpreF in the prevention of LRTI-RSV in adults.

Accepts healthy volunteers
  • 163 views
  • 18 Sep, 2022
  • 234 locations
PROcalcitonin Impact on Antibiotic Reduction, adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT (ProSAVE)

prescription guided by a PCT-algorithm via a Stewardship Team over standard guidelines in hospitalized adult patients with suspected or confirmed LRTI (including sepsis with respiratory focus).

community acquired pneumonia
antibiotic therapy
procalcitonin
antibiotics
  • 23 views
  • 11 Mar, 2022
  • 4 locations
Sphingosine-1-phosphate and Pneumonia (SOPN)

Pneumonia is a major infectious cause of death worldwide and imposes a considerable burden on healthcare resources. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid and involved in many physiological processes including immune responses and endothelial barrier integrity. In term of endothelial barrier integrity, S1P plays a crucial role in protecting lungs …

community acquired pneumonia
  • 0 views
  • 11 Feb, 2022
  • 1 location
Variable Immobilization Protocol for Arthroplasty of the Carpometacarpal Joint of the Thumb

Thumb carpometacarpal (CMC) osteoarthritis (OA) is common, seen frequently in middle-aged and elderly women. While a variety of surgical treatments have been described with none superior to any other, there is no consensus on the optimal duration of postoperative immobilization. Immobilization following surgery is critical for wound healing, pain control, …

  • 0 views
  • 26 May, 2022
  • 1 location
Head-of-Bed Positioning in Large Artery Acute Ischemic Stroke

Positioning of the patient with hyperacute large artery ischemic stroke (IS) is an important, yet understudied aspect of care that could impact the course of treatment and ultimately clinical outcome. Positioning with the head of bed (HOB) at 0-degree has been shown in small studies to increase cerebral blood flow …

  • 0 views
  • 17 Oct, 2021
  • 2 locations
A Study in Infants With RSV LRTI to Evaluate RV521 (REVIRAL 1)

Virus (RSV) lower respiratory tract infection (LRTI). Due to the adaptive study design, the number of enrolled subjects may vary depending on the obtained PK and safety profiles.

respiratory tract infection
antiviral
  • 31 views
  • 22 Mar, 2022
  • 32 locations
  • 0 views
  • 15 Sep, 2022
  • 20 locations
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.

immunodeficiency
covid-19
stem cell transplantation
das181
respiratory tract infection
  • 2805 views
  • 19 Jun, 2022
  • 40 locations
A Randomised Controlled Trial in HIV-1 Exposed Ugandan Infants to Estimate Additional Benefits (Non-specific Effects) of BCG

BCG vaccination may have non-specific effects (NSE) i.e., additional benefits on childhood morbidity and mortality that are separate the vaccine's effect on the incidence of disseminated tuberculosis. Though the available literature is mostly from observational study designs, and is fraught with controversy, BCG vaccination at birth, in a high risk …

interleukin-6
Accepts healthy volunteers
antiretroviral
bcg vaccine
vaccination
  • 21 views
  • 22 Sep, 2022
  • 1 location