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Found 47 clinical trials
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N0577 (CODEL) Phase III Intergroup Study of Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q co-deleted Anaplastic Glioma or Low Grade Glioma

People who are diagnosed with an oligodendroglioma and who haven't yet undergone treatment may be eligible.  This study is comparing two standard regimens, radiation followed by PCV (Procarbazine, CCNU, and Vincristine) or radiation with temozolomide during and after radiation, to see which is better.  

brain tumor
temozolomide
vincristine
brain tumors
oligodendroglioma
  • 10 views
  • 24 Jun, 2021
  • 1 location
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)

Grade Glioma aged 6 months to less than18 years of age at the time of initiation of therapy. Participants will be randomized to Arm A or Arm B. Arm A includes 68 weeks of single agent Vinblastine

progressive disease
platelet count
vinblastine
BRAF
glomerular filtration rate
  • 0 views
  • 24 Jan, 2021
  • 24 locations
  • 0 views
  • 01 Aug, 2021
  • 13 locations
  • 167 views
  • 28 Jul, 2021
  • 126 locations
Everolimus in Treating Patients With Recurrent or Progressive Low-Grade Glioma

studying how well everolimus works in treating patients with recurrent or progressive low-grade glioma.

  • 14 views
  • 07 Nov, 2020
  • 1 location
A Vaccine Trial for Low Grade Gliomas

The study will assess the immunogenicity, safety and preliminary clinical efficacy of the glioma associated antigen (GAA)/tetanus toxoid (TT) peptide vaccine and poly-ICLC in HLA-A2+ children with unresectable low-grade gliomas that have received at least two chemotherapy/biologic regimens. Radiation therapy counts as one biologic regimen, but patients may not have …

dexamethasone
toxoid
corticosteroids
  • 54 views
  • 25 Jan, 2021
  • 1 location
Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Patients with glial brain tumors have increasingly improved outcomes, with median survival of 5-15 years. However, the treatments, including surgery, radiation, and chemotherapy, often lead to impaired attention, working memory, and other cognitive functions. These cognitive deficits frequently have significant impact on patient quality of life. Although currently, there is …

brain tumor
MRI Scan
karnofsky performance status
stroke
seizure
  • 0 views
  • 25 Jan, 2021
  • 1 location
Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery

It has been reported that radiation therapy followed by PCV chemotherapy (procarbazine, lomustine and vincristine) could improve progression-free survival (PFS) and overall survival (OS) in patients with high-risk WHO grade 2 gliomas after surgery. However, procarbazine is not available in China. In clinical practice, Chinese doctors often use radiotherapy combined …

temozolomide
lomustine
vincristine
  • 1 views
  • 24 Jan, 2021
  • 1 location
TAK-580 In Gliomas and Other Tumors

This research study is studying a drug TAK-580 (MLN2480) as a possible treatment a low-grade glioma that has not responded to other treatments. The name of the study drug involved in this

ejection fraction
measurable disease
tak-580
  • 3 views
  • 16 Jul, 2021
  • 14 locations
A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

An open label single-arm clinical trial to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of HMPL-306 in advanced or metastatic solid tumors with IDH mutation.

  • 0 views
  • 03 Jun, 2021
  • 2 locations