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Found 42 clinical trials
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)

Grade Glioma aged 6 months to less than18 years of age at the time of initiation of therapy. Participants will be randomized to Arm A or Arm B. Arm A includes 68 weeks of single agent Vinblastine

vinblastine
glomerular filtration rate
auditory test
platelet count
corticosteroids
  • 2 views
  • 27 Jan, 2022
  • 24 locations
  • 0 views
  • 07 Dec, 2021
  • 23 locations
  • 198 views
  • 07 Apr, 2022
  • 136 locations
HyperSpectral Imaging in Low Grade Glioma

Low grade glioma (LGG) is a slowly evolving, highly invasive intrinsic brain tumor displaying only subtle tissue differences with the normal surrounding brain, hampering the attempts to visually

  • 0 views
  • 14 Oct, 2021
  • 1 location
Everolimus in Treating Patients With Recurrent or Progressive Low-Grade Glioma

studying how well everolimus works in treating patients with recurrent or progressive low-grade glioma.

  • 24 views
  • 07 Nov, 2020
  • 1 location
A Vaccine Trial for Low Grade Gliomas

The study will assess the immunogenicity, safety and preliminary clinical efficacy of the glioma associated antigen (GAA)/tetanus toxoid (TT) peptide vaccine and poly-ICLC in HLA-A2+ children with unresectable low-grade gliomas that have received at least two chemotherapy/biologic regimens. Radiation therapy counts as one biologic regimen, but patients may not have …

dexamethasone
toxoid
corticosteroids
  • 62 views
  • 12 Aug, 2021
  • 1 location
Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery

It has been reported that radiation therapy followed by PCV chemotherapy (procarbazine, lomustine and vincristine) could improve progression-free survival (PFS) and overall survival (OS) in patients with high-risk WHO grade 2 gliomas after surgery. However, procarbazine is not available in China. In clinical practice, Chinese doctors often use radiotherapy combined …

vincristine
temozolomide
lomustine
  • 1 views
  • 02 Mar, 2022
  • 1 location
Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Patients with glial brain tumors have increasingly improved outcomes, with median survival of 5-15 years. However, the treatments, including surgery, radiation, and chemotherapy, often lead to impaired attention, working memory, and other cognitive functions. These cognitive deficits frequently have significant impact on patient quality of life. Although currently, there is …

MRI Scan
stroke
brain tumor
seizure
karnofsky performance status
  • 0 views
  • 23 Aug, 2021
  • 1 location
The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier

The limitation of treating intrinsic brain pathologies has been circumvented with neurosurgical techniques; however, less invasive approaches may be desirable particularly for widespread or multifocal disease and when long term and repetitive administration is required. This study seeks to investigate the efficacy of focused ultrasound. Patients with either low grade …

  • 0 views
  • 12 Sep, 2021
  • 1 location
A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

An open label single-arm clinical trial to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of HMPL-306 in advanced or metastatic solid tumors with IDH mutation.

  • 0 views
  • 13 Mar, 2022
  • 8 locations