Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 39 clinical trials
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)

Grade Glioma aged 6 months to less than18 years of age at the time of initiation of therapy. Participants will be randomized to Arm A or Arm B. Arm A includes 68 weeks of single agent Vinblastine

corticosteroids
auditory test
vinblastine
glomerular filtration rate
BRAF
  • 6 views
  • 27 Jan, 2022
  • 24 locations
  • 198 views
  • 07 Apr, 2022
  • 136 locations
HyperSpectral Imaging in Low Grade Glioma (HSI-LGG-2019)

Low grade glioma (LGG) is a slowly evolving, highly invasive intrinsic brain tumor displaying only subtle tissue differences with the normal surrounding brain, hampering the attempts to visually

  • 0 views
  • 25 May, 2022
  • 1 location
Everolimus in Treating Patients With Recurrent or Progressive Low-Grade Glioma

studying how well everolimus works in treating patients with recurrent or progressive low-grade glioma.

  • 24 views
  • 07 Nov, 2020
  • 1 location
Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery

It has been reported that radiation therapy followed by PCV chemotherapy (procarbazine, lomustine and vincristine) could improve progression-free survival (PFS) and overall survival (OS) in patients with high-risk WHO grade 2 gliomas after surgery. However, procarbazine is not available in China. In clinical practice, Chinese doctors often use radiotherapy combined …

vincristine
temozolomide
lomustine
  • 1 views
  • 02 Mar, 2022
  • 1 location
A Vaccine Trial for Low Grade Gliomas

The study will assess the immunogenicity, safety and preliminary clinical efficacy of the glioma associated antigen (GAA)/tetanus toxoid (TT) peptide vaccine and poly-ICLC in HLA-A2+ children with unresectable low-grade gliomas that have received at least two chemotherapy/biologic regimens. Radiation therapy counts as one biologic regimen, but patients may not have …

toxoid
dexamethasone
corticosteroids
  • 62 views
  • 12 Aug, 2021
  • 1 location
The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier

The limitation of treating intrinsic brain pathologies has been circumvented with neurosurgical techniques; however, less invasive approaches may be desirable particularly for widespread or multifocal disease and when long term and repetitive administration is required. This study seeks to investigate the efficacy of focused ultrasound. Patients with either low grade …

  • 0 views
  • 12 Sep, 2021
  • 1 location
A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

An open label single-arm clinical trial to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of HMPL-306 in advanced or metastatic solid tumors with IDH mutation.

  • 0 views
  • 13 Mar, 2022
  • 8 locations
LIQUID BIOPSY IN Low-grade Glioma Patients (GLIOLIPSY)

Diffuse low-grade gliomas (DLGG) (or WHO grade II gliomas) are rare tumors, with an incidence estimated at 1/105 person-year. DLGG are characterized by a continuous growth and an unavoidable anaplastic transformation. DLGG malignant progression is classically characterized by a continuum, from grade II to grade III or IV tumors. To …

MRI
  • 0 views
  • 26 Mar, 2022
  • 1 location
Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy (PLGG - MEKTRIC)

Pediatric low-grade glioma (PLGG) is a heterogeneous group of WHO grade I and II brain tumors, associated with a 10-year overall survival of 90%. It is the most common form of primary central

  • 0 views
  • 04 Oct, 2022
  • 1 location