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Found 82 clinical trials
Low-Density Lipoprotein Cholesterol-targeting Statin Therapy Versus the Intensity-based Statin Therapy in Patients With Coronary Artery Disease: a Randomized Comparison Trial

To compare clinical safety & efficacy of fixed-high potent statin therapy (according to 2013 ACC/AHA guideline) vs. targeted LDL-C goal statin therapy (LDL<70mg/dL) for secondary prevention. Total 4400 patients with coronary artery disease patients requiring statin treatment were categorized fixed high-potent statin group and targeted LDL-C group. The investigators will …

  • 22 Jan, 2021
Evaluate the Efficacy and Safety of Evinacumab in Pediatric Patients With Homozygous Familial Hypercholesterolemia

objective for Part B of the study is to demonstrate a reduction of low-density lipoprotein cholesterol (LDL-C) by evinacumab in pediatric (5 to 11 years of age) patients with HoFH. The secondary

  • 14 Jul, 2021
  • 11 locations
Efficacy and Safety Of Alirocumab to Prevent Early Cardiac Allograft Vasculopathy in Recent Heart Transplant Recipients

-density lipoprotein cholesterol (LDL-C) is very common after transplantation with nadir of LDL levels occurring at 6 months. Because of drug-drug interactions, heart transplant recipients cannot be

  • 21 Feb, 2021
  • 3 locations
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism

The aim of this study is to identify new targets in cholesterol metabolism thanks to a genetically-based strategy.

  • 07 Aug, 2021
  • 1 location
Effect of Diet Induced Ketosis on LDL Turnover Rates

There have been concerning case reports of marked elevations of LDL-c in some individuals consuming a KD and Dr. Lewis has been referred a number of these cases to his lipid clinic, some of whom have had extreme elevations of LDL that mimic familial hypercholesterolemia. These marked elevations of LDLc …

Accepts healthy volunteers
  • 17 Nov, 2021
  • 1 location
Sacha Inchi Oil Supplementation in 3Hs

The objective of this study is to evaluate the effect of Sacha Inchi Oil supplementation among the 3Hs patients.

  • 21 Jun, 2021
  • 1 location
Topical Vancomycin Over Sternal Edge in Cardiac Surgery

This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical application of vancomycin paste over sternum edge is safe and can reduce sternal wound infection after elective cardiac surgery. Vancomycin paste will be prepared using 2.5 g of vancomycin mixed with 2 ml normal saline. Vancomycin …

  • 12 Sep, 2021
  • 1 location
Study in Primary Care Evaluating Inclisiran Delivery Implementation + Enhanced Support

The purpose of the study is to find out if a study treatment called Inclisiran can be given in regional primary care setting (i.e. at a GP surgery in the NHS) in the UK, and to understand how this health care service may be set-up by the NHS. Inclisiran, also …

  • 08 Dec, 2021
  • 10 locations
Safety and Efficacy of IBI306 in Chinese Subjects With Non-familiar Hypercholesterolemia

IBI306 is a fully human monoclonal antibody that binds proprotein convertase substilisin/kexin type 9 (PCSK-9), preventing its interaction with the low-density lipoprotein cholesterol receptor

hmg-coa reductase inhibitors
low density lipoprotein
monoclonal antibody
lipoprotein cholesterol
cholesterol measurement
  • 27 Jan, 2021
  • 1 location
  • 16 Dec, 2021
  • 83 locations